Menopause and risk factors for coronary heart disease

The New England Journal of Medicine
K A MatthewsR R Wing

Abstract

Postmenopausal women are believed to have a higher risk of coronary artery disease than premenopausal women. In this study, we prospectively determined changes in coronary risk factors that were attributable to natural menopause in 541 healthy, initially premenopausal women 42 to 50 years of age. After approximately 2 1/2 years, 69 women had spontaneously stopped menstruating for at least 12 months, and 32 women had stopped natural menstruation and received hormone-replacement therapy for a period of at least 12 months. An equal number of age-matched premenopausal women in the study group served as controls. In women who had a natural menopause and did not receive hormone-replacement therapy, serum levels of high-density lipoprotein (HDL) cholesterol declined as compared with those of premenopausal controls (-0.09 vs. 0.00 mmol per liter; P = 0.01), and levels of low-density lipoprotein (LDL) cholesterol increased (+0.31 vs. +0.14 mmol per liter; P = 0.04). In menopausal women who received hormone-replacement therapy, HDL and LDL cholesterol levels did not change, but the levels of triglycerides (+0.42 vs. -0.04 mmol per liter; P less than 0.001), apolipoprotein A-I (+0.18 vs. +0.03 g per liter; P less than 0.01), and apolipopr...Continue Reading

References

Aug 1, 1978·Annals of Internal Medicine·T GordonP M McNamara
Sep 1, 1978·American Journal of Epidemiology·R S PaffenbargerR T Hyde
Oct 1, 1976·Annals of Internal Medicine·W B KannelT Gordon
Mar 1, 1976·American Journal of Epidemiology·M C HjortlandW B Kannel
Sep 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E N MeilahnK A Matthews
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·H CamposE J Schaefer
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Jan 1, 1985·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·O LindquistL Lapidus
Sep 1, 1985·Annals of Internal Medicine·S M McKinlayJ B McKinlay
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Jun 1, 1983·American Journal of Epidemiology·W WillettC H Hennekens
Jul 1, 1981·Circulation·C BainF E Speizer
Dec 7, 1963·Lancet·J S GARROW

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Citations

Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L M SalamoneJ A Cauley
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L M SalamoneJ A Cauley
Nov 1, 1993·Breast Cancer Research and Treatment·R Vassilopoulou-Sellin
Jan 1, 1995·Journal of Thrombosis and Thrombolysis·E N Meilahn
Sep 30, 2005·Diabetologia·I F Godsland
Feb 12, 2009·European Journal of Applied Physiology·Juan C ColadoJosé Abellán
Dec 21, 2000·Current Atherosclerosis Reports·B V Howard, M F Magee
Dec 21, 2000·Current Atherosclerosis Reports·L Mosca
Nov 5, 2003·Current Hypertension Reports·Jane Morley Kotchen, Theodore A Kotchen
Mar 13, 2009·Current Hypertension Reports·Louai Razzouk, Paul Muntner
Feb 9, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A H E M Maas, Y E A Appelman
Jul 1, 1994·Journal of the American Dietetic Association·C A CarsonA W Caggiula
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M DnistrianD C Schwartz
Feb 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A E Omu, N Al-Qattan
Jan 4, 1993·Atherosclerosis·J C StevensonI F Godsland
Aug 1, 1994·Atherosclerosis·V T Miller
Oct 1, 1995·Metabolism: Clinical and Experimental·S J RobinsJ M Ordovas
Dec 28, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R LindgrenA G Olsson
Oct 1, 1996·Thrombosis Research·G F GensiniR Abbate
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Oct 1, 1994·Pharmacology & Therapeutics·J A Gevers Leuven
Jun 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J WuJ Bonnar
May 1, 1994·Experimental Gerontology·K A MatthewsE N Meilahn
May 1, 1994·Experimental Gerontology·L H KullerK A Matthews
Jun 19, 2004·International Journal of Cardiology·Jaffar Ali RazaAssad Movahed
Jan 9, 2004·The Journal of Nutritional Biochemistry·Anne MoriseDominique Hermier
Feb 10, 2004·Metabolism: Clinical and Experimental·André P Van BeekTjerk W A de Bruin
Nov 15, 1995·The American Journal of Cardiology·T KangroI Ringqvist

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