Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome

Journal of Internal Medicine
P HennemanK Willems van Dijk

Abstract

Plasma adiponectin is negatively correlated with metabolic syndrome (MetS) components obesity and insulin sensitivity. Here, we set out to evaluate the effect of menopause on the association of plasma adiponectin with MetS. Data on plasma adiponectin and MetS were available from 2256 individuals participating in the Erasmus Rucphen Family study. Odds ratios for MetS were calculated by logistic regression analysis using plasma adiponectin quartiles. The discriminative accuracy of plasma adiponectin for MetS was determined by calculating the area under the curve (AUC) of receiver operator. Analyses were performed in women and men, pre- and postmenopausal women and younger and older men. Virtually all determinants of MetS differed significantly between groups. Low plasma adiponectin showed the highest risk for MetS in postmenopausal women (odds ratio = 18.6, 95% CI = 7.9-44.0). We observed a high discriminative accuracy of age and plasma adiponectin for MetS not only in postmenopausal women (AUC = 0.76) but also in other subgroups (AUC from 0.67 to 0.87). However, in all groups, the discriminative accuracy of age and body mass index (BMI) for MetS was similar to the discriminative accuracy of age and plasma adiponectin. Low plasma...Continue Reading

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Citations

Aug 1, 2013·European Journal of Clinical Investigation·Concetta IraceFrancesco Squadrito
Dec 30, 2014·Genes & Nutrition·Kerstin RohdeYvonne Böttcher
Jan 22, 2011·Menopause : the Journal of the North American Menopause Society·Yacine LoucifDaniel Gaudet
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Nov 20, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Katie E CohenJulie K Freed

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