PMID: 8944857Oct 1, 1996Paper

Menopause, menstrual and reproductive history, and bone density in northern Italy

Journal of Epidemiology and Community Health
F ParazziniR Zecchin

Abstract

To analyse the relationship between menstrual and reproductive factors and the risk of low bone mineral density (BMD). This was a population based screening programme carried out between 1991 and 1993 among 1373 perimenopausal women in northern Italy by means of dual photon absorptiometry at the lumbar spine. BMD was strongly related to the age at menopause. In comparison with women reporting menopause below 45 years of age, the odds ratios (OR) of being in the lowest compared with the highest BMD tertile were 0.7 (95% confidence interval (CI) 0.3,1.5) and 0.3 (95% CI 0.1,0.8), respectively, in those with menopause at age 45-49 and above 50 years: the trend in risk was significant. Likewise, the risk of being in the lowest tertile increased with years since the menopause. Compared with women who reported they had undergone the menopause less than two years before interview, the OR of being in the lowest BMD tertile were 2.1 (95% CI 1.1,4.3), 2.3 (95% CI 1.1, 5.0), and 5.7 (95% CI 2.5,12.9) respectively in women who reported menopause 2-5, 6-9, and > or = 10 years earlier. The protective effect on bone density of late age at menopause was observed in different strata of years since menopause. Likewise, the increasing risk of a l...Continue Reading

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Citations

Feb 19, 1999·Journal of Epidemiology and Community Health·B K JacobsenG Kvåle
Feb 24, 2009·Stroke; a Journal of Cerebral Circulation·Lynda D LisabethPhilip A Wolf
Jun 22, 2013·American Journal of Epidemiology·Ellen B GoldSiobán D Harlow
Mar 16, 2011·Climacteric : the Journal of the International Menopause Society·C C KhooT Kwok
Oct 4, 2011·Obstetrics and Gynecology Clinics of North America·Ellen B Gold
May 29, 2003·American Journal of Physical Anthropology·Antonietta M CerroniMarc D Grynpas
Dec 1, 2006·Maturitas·Abdellah El MaghraouiMohamed Adnane Tazi
Feb 15, 2001·American Journal of Obstetrics and Gynecology·A TavaniS Franceschi
Mar 28, 2013·Menopause : the Journal of the North American Menopause Society·Rupa KanapathipillaiMichelle Giles
Mar 20, 2019·Menopause : the Journal of the North American Menopause Society·Sybil L Crawford
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A StreetenBraxton D Mitchell
Jun 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Ning DingSung Kyun Park
Oct 17, 2018·International Journal of Molecular Sciences·Swati AgarwalAsif Ahmed
Jun 2, 2020·Human Reproduction Update·Ning DingSung Kyun Park

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