Menopause, mild psychological stress and salivary cortisol: influence of long-term hormone replacement therapy (HRT)

Maturitas
F R PatacchioliG Perrone

Abstract

Aim of the present study was to examine the adrenocortical activity in basal condition and following a mild stress exposure in long-term HRT-treated menopausal women. Menopausal women, long term users of HRT (14 subjects) were compared both to menopausal women who had never used HRT (14 subjects) and young pre-menopausal women (14 subjects). Morning and evening salivary cortisol secretion was measured in samples collected twice a day (08:00 in the morning and 08:00 in the evening). Mild stress response was evoked by administration of the Stroop color-word test (CWT). Salivary cortisol was measured immediately before the start, 15, 30 and 45 min after the completion of the test. Menopause appears not to be associated with an impairment of cortisol circadian fluctuation. Long-term use of HRT in menopause attenuated HPA activity either in basal condition or in response to mild stress exposure. With regard to the CWT performance, all menopausal women took significantly longer than young women to perform the test. However, long-term HRT significantly reduced the number of errors made during the test. The present study suggested that long-term HRT could help menopausal patients to cope with mild stress and to improve mental performan...Continue Reading

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Citations

Jun 4, 2011·Clinical Oral Investigations·Laura TarkkilaJukka H Meurman
Jul 16, 2011·Development and Psychopathology·Robert-Paul JusterSonia J Lupien
Sep 4, 2013·Hormones and Behavior·Hanan D TrotmanElaine F Walker
Jun 12, 2010·Stress : the International Journal on the Biology of Stress·Julie M Turner-CobbDavid S Jessop
Jan 21, 2015·Climacteric : the Journal of the International Menopause Society·F R PatacchioliG Perrone
Feb 11, 2015·Climacteric : the Journal of the International Menopause Society·F H Comhaire, H T Depypere
Nov 6, 2015·Psychoneuroendocrinology·Robert-Paul JusterSonia J Lupien
Aug 5, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·C LeminiL Martínez-Mota
Aug 19, 2011·Annals of Indian Academy of Neurology·Kameshwar PrasadAsha Bakshi
Dec 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariyawan TantipongpiradetYaowared Chulikhit
Aug 21, 2008·Menopause International·Oliver T Wolf, Brigitte M Kudielka
Jun 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Gioia M GuerrieriPeter J Schmidt

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