Menopause-Related Estrogen Decrease and the Pathogenesis of HFpEF: JACC Review Topic of the Week

Journal of the American College of Cardiology
Andrea Rodrigues Sabbatini, Georgios Kararigas

Abstract

Heart failure (HF) is a complex condition affecting >40 million people worldwide. It is defined by failure of the heart to pump (HF with reduced ejection fraction) or by the failure of the heart to relax, resulting in reduced filling but with preserved ejection fraction (HFpEF). HFpEF affects approximately 50% of patients with HF, most of whom are women. Given that the annual mortality ranges from 10% to 30% and as there are no treatments specifically directed for HFpEF, there is a need for better understanding of the underlying mechanisms of this condition. We put forward the hypothesis that the decline of estrogen at menopause might contribute to the pathogenesis of HFpEF and we highlight potential underlying mechanisms of estrogen action, which may attenuate the development of HFpEF. We also discuss areas in which additional research is needed to develop new approaches for prevention and treatment of HFpEF.

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Citations

Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bochra TourkiGanesh V Halade
Jun 20, 2020·Current Atherosclerosis Reports·Gina LundbergNanette Wenger
Jun 4, 2020·Biology of Sex Differences·Andrea Rodrigues Sabbatini, Georgios Kararigas
Apr 9, 2020·Frontiers in Endocrinology·Dawn A Lowe, Georgios Kararigas
Mar 7, 2021·Mayo Clinic Proceedings·Oliver Ritter, Georgios Kararigas
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Du XiangYanfeng Wang
Aug 29, 2020·Journal of the American College of Cardiology·Marco GuazziYochai Adir
Jun 16, 2021·Menopause : the Journal of the North American Menopause Society·Wendy YingDhananjay Vaidya
Oct 27, 2021·Physiological Reviews·Georgios Kararigas

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