Men's and women's response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder

Substance Abuse Treatment, Prevention, and Policy
Heather PalisEugenia Oviedo-Joekes

Abstract

To test whether there are gender differences in treatment outcomes among patients receiving injectable opioids for the treatment of long-term opioid-dependence. The study additionally explores whether men and women have different perceptions of treatment effectiveness. This study is a secondary analysis from SALOME, a double-blind, phase III, randomized controlled trial testing the non-inferiorirty of injectable hydromorphone to injectable diacetylmorphine among 202 long-term street opioid injectors in Vancouver (Canada). Given this was a secondary analysis, no a priori power calaculation was conducted. Differences in baseline characteristics and six-month treatment outcomes (illicit heroin use, opioid use, crack cocaine use, non-legal activities, physical and psychological health scores, urine positive for street heroin markers, and retention) were analysed by gender using fitted models. Responses to an open ended question on reasons for treatment effectiveness were explored with a thematic analysis. Men and women differed significantly on a number of characteristics at baseline. For example, women were significantly younger, presented to treatment with significantly higher rates of prior month sex work (31.5% vs. 0%), and use...Continue Reading

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Citations

May 28, 2019·The American Journal on Addictions·Andrew S HuhnKelly E Dunn
May 10, 2019·Clinical Psychology & Psychotherapy·Jessica BernardiLaura Jobson
Aug 8, 2020·Endocrinology·Samuel J HarpEmilie F Rissman
Oct 30, 2020·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Andrew IvsinsRyan McNeil
Jan 7, 2021·Addiction·Jordan P DavisJohn F Kelly

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Software Mentioned

NVivo
SALOME

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