PMID: 16648793May 2, 2006Paper

Menstrual cycle and sex hormone profile in kidney-transplanted women

Neuro Endocrinology Letters
Bronislawa PietrzakKatarzyna Bobrowska

Abstract

End-stage renal failure is associated with amenorrhaea and extremely reduced fertility. After successful kidney transplantation restoration of menstrual function is observed. The aim of the study was to investigate ovarian function and menstrual cycles in kidney-transplanted women of reproductive age. 55 ovarian cycles in kidney transplanted women, aged 18-40 years, being one to five years after transplantation, were analyzed and compared with 50 cycles of healthy women. The duration of the cycles as well as FSH, LH, estradiol, progesterone, prolactin and testosterone serum concentrations were monitored. Simultaneously the presence of ovulation was evaluated with repeated sonographic examinations. Regular menstrual cycles were observed in 72.7% of kidney transplanted women. The rates of ovulatory cycles were similar in the study group and the control: 65% and 70% respectively. Mean estradiol level in the follicular phase of the cycle was significantly higher in transplant patients (205.9, SD 160.22 vs 135.9 pg/ml, SD 68.34 in the control). Significantly lower levels of progesterone (13.2 ng/ml, SD 14.2 vs 26.7 ng/ml, SD 14.1 in the control) and testosterone were observed in kidney recipients. Other hormonal parameters did not d...Continue Reading

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