Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy

Seizure : the Journal of the British Epilepsy Association
Christoph HelmstaedterJuri-Alexander Witt

Abstract

Functional transcranial Doppler sonography (fTCD) is a valid and non-invasive tool for determining language dominance, e.g. in the context of presurgical evaluations. Beyond this, fTCD might be an ideal tool to study dynamics in language dominance over time. However, an essential prerequisite would be a high test-retest reliability. This was addressed in the present study. Test-retest reliability of hemispheric hemodynamics during open speech was determined in 11 male and 11 female healthy volunteers using the Animation Description Paradigm. Expressive language dominance was assessed weekly over an interval of 4-5 weeks. Internal consistency of the four measurements was excellent (split-half reliability 0.85-0.95), but test-retest reliability of the lateralization index was poor to moderate (rtt=0.37-0.74). Controlling for gender, test-retest reliabilities were better in men (rtt=0.67-0.78) as compared to women (rtt=0.04-0.70). When arranging the assessments in women around day one of menstruation - all were on contraceptives - a significant shift from left hemisphere dominance toward bilaterality (t=2.2 p=0.04) was evident around menstruation with significant reversal afterwards (t=-3.4 p=0.005). A high intraindividual variabi...Continue Reading

References

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Citations

Aug 13, 2015·The Journal of Infectious Diseases·Lynne M Mofenson
Oct 5, 2020·Acta Neurologica Scandinavica·Magdalena SeethalerElisabeth Kaufmann

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