Menstrual cycle effects on the neurohumoral and autonomic nervous systems regulating the cardiovascular system

The Journal of Clinical Endocrinology and Metabolism
Nir HirshorenGiris Jacob

Abstract

Gonadal hormones may affect homeostatic mechanisms regulating the cardiovascular system. We investigated this relationship at five different crucial hormonal time points along the menstrual cycle. Eight eumenorrheic healthy subjects underwent a battery of autonomic tests, hemodynamics, and volume-regulatory hormone measurements. Fluid-regulatory hormones, plasma renin activity, and aldosterone increased along the luteal phase (P = 0.003 and 0.02, respectively), whereas rest supine-corrected hematocrit declined in the course of the menstrual cycle (P = 0.001). Plasma norepinephrine decreased from 1.4 +/- 0.2 to 0.95 +/- 0.1 nmol/liter (P < 0.02) [early follicular (EF) to late follicular]. Thereafter, concentrations gradually returned to EF levels. Lf to Hf domain ratio (spectral analysis of electrocardiogram) showed a difference from that of norepinephrine. The cardiovagal baroreflex sensitivity increased significantly along the luteal phase (P = 0.04). The dose of isoproterenol required to increase heart rate (HR) 15 beats per minute was 0.19 +/- 0.04 microg during the EF time point, and it increased to 0.39 +/- 0.06 microg during the late luteal time point (P = 0.05). However, blood pressure, HR, and their responses to orthost...Continue Reading

References

Jan 1, 1990·Clinical Science·A A HassanJ E Tooke
Sep 1, 1990·Clinical Obstetrics and Gynecology·R T Scott, G D Hodgen
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·L A StephensonR R Gonzalez
Aug 1, 1989·Journal of Applied Physiology·M J De SouzaK L Goetz
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·S P BottariG P Vauquelin
Jun 1, 1988·Clinical Endocrinology·C J ThompsonP H Baylis
Jan 1, 1988·The Journal of Clinical Investigation·D S GoldsteinI J Kopin
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·B E KarlbergK Wichman
Aug 1, 1983·American Journal of Obstetrics and Gynecology·D S GoldsteinH R Keiser
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·V A ConvertinoJ E Greenleaf
Oct 1, 1993·Journal of Affective Disorders·J Endicott
Jul 22, 1993·The New England Journal of Medicine·N K WengerB Packard
Apr 1, 1996·Steroids·M Perrot-Applanat
Jun 1, 1996·Cellular and Molecular Neurobiology·R Alonso-SolísA Hernández
Aug 1, 1997·The American Journal of Medicine·G JacobI Biaggioni
Oct 23, 1997·Journal of the Autonomic Nervous System·Y SaekiT Yoshizawa
Dec 31, 1997·Circulation·D L Eckberg
Apr 16, 1998·Journal of Applied Physiology·G JacobD Robertson
Dec 8, 1998·Journal of Applied Physiology·S M EttingerL I Sinoway
Mar 6, 1999·Journal of Applied Physiology·N S StachenfeldE R Nadel
May 20, 2000·American Journal of Obstetrics and Gynecology·M E SpaandermanL L Peeters
Oct 6, 2000·The New England Journal of Medicine·G JacobD Robertson

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Citations

May 5, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jessica A JiménezLinda C Gallo
Mar 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert K GoldmanVirginia L Brooks
Nov 23, 2012·Hypertension·Jason R CarterMichael J Joyner
Feb 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Natalia M ArzenoSteven H Platts
Jul 21, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Giris Jacob
Feb 1, 2007·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Gemma D Bishop, Margaret D Brown
Mar 4, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Yannick Tousignant-Laflamme, Serge Marchand
Nov 1, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Poorvi KulshreshthaKishore Kumar Deepak
Apr 12, 2012·Archives of Gynecology and Obstetrics·Dorota ZyśkoJerzy Rudnicki
Jun 10, 2010·Journal of Psychopharmacology·N J KalkA R Lingford-Hughes
Feb 9, 2008·Hypertension·Rimma RosenfeldGiris Jacob
May 10, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Victoria Elizabeth ClaydonRoger Hainsworth
Aug 31, 2006·American Journal of Physical Anthropology·Tessa M PollardJoseph E Schwartz
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartMark M Millonas
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartLeslie D Montgomery
Jul 27, 2006·The Journal of Clinical Endocrinology and Metabolism·Emily D SzmuilowiczEllen W Seely
May 20, 2006·Journal of Applied Physiology·Megan M WennerWilliam B Farquhar
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shahar LaviGiris Jacob
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shahar LaviGiris Jacob
Apr 28, 2007·Journal of Applied Physiology·Stacy T SimsJames D Cotter
Feb 22, 2012·Journal of Applied Physiology·S S JarvisJ A Pawelczyk
May 24, 2014·Physiological Measurement·Z VisnovcovaI Tonhajzerova
Jun 20, 2014·Psychophysiology·Matthew S TenanLisa Griffin
Jul 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Vienna E BruntChristopher T Minson
Feb 17, 2007·Cardiology in Review·Marvin S Medow, Julian M Stewart
Jan 25, 2005·Human Reproduction·J M J SmeenkD D M Braat
Nov 7, 2015·Journal of Sleep Research·Joanna M WaloszekJohn Trinder
Sep 4, 2015·Psychophysiology·André L TeixeiraDjalma R Ricardo
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartBenjamin H Natelson
Oct 12, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heather EdgellRichard L Hughson
Jan 12, 2007·Journal of Psychosomatic Obstetrics and Gynaecology·Tamaki MatsumotoNoriyuki Tatsumi
Oct 13, 2007·The Journal of Physiology·Jason R Carter, Johnathan E Lawrence
Apr 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen A KlassenDeborah D O'Leary
Sep 9, 2017·Frontiers in Physiology·Julian KoenigMichael Kaess
Oct 18, 2018·Frontiers in Physiology·Rimma KoifmanGiris Jacob
Jan 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph SchroederJens Jordan

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