Mental and Emotional Impairment in Patients With Hepatitis C is Related to Lower Work Productivity

Psychosomatics
Issah YounossiZobair Younossi

Abstract

Patients with Hepatitis C virus (HCV) have a higher risk of developing mental and emotional health (MEH) issues compared with the general population. Our aim was to assess the relationship between MEH and work productivity (WP) in patients with HCV. Patients with HCV enrolled in multinational clinical trials completed 4 questionnaires (Short Form 36 [SF-36], the Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F], Chronic Liver Disease Questionnaire-Hepatitis C Virus [CLDQ-HCV], and the WP and Activity-Specific Health Problem [WPAI:SHP]) while they were not under treatment. The emotional domain (EM) of CLDQ-HCV, the role emotional, mental health, and the mental summary score of the SF-36 were used as the MEH indicators. We compared patients with an EM score of less than 4.66 (range: 1-7), which is the lowest quartile of emotional health, and those with an EM score of more than 6.33, which is the topmost quartile. A total of 4333 patients were enrolled. Of those, 3,888 had MEH issues and WP data available. Patients were 52.3 ± 9.9 years old, 65.8% of them were male, 63.7% were treatment naïve, 19.7% were cirrhotic, 29.0% reported having a history of depression, and 18.7% had a history of anxiety. Patients at the t...Continue Reading

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Citations

Mar 3, 2017·Nature Reviews. Disease Primers·Michael P MannsZobair Younossi
Sep 29, 2017·Journal of Pediatric Gastroenterology and Nutrition·Zobair M YounossiSharon Hunt
Dec 2, 2017·Journal of Viral Hepatitis·Z M YounossiS Hunt
Jun 13, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Zobair M YounossiAndrei Racila
Nov 7, 2018·Journal of Viral Hepatitis·Zobair YounossiAngelos Hatzakis
Feb 1, 2019·Journal of Clinical Gastroenterology·Zobair M YounossiLinda Henry
Apr 6, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zobair M YounossiAndrei Racila
Mar 29, 2019·World Journal of Gastroenterology : WJG·Ilias GountasAngelos Hatzakis
Jul 19, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Zobair YounossiSharon Hunt
Jun 8, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Zobair M YounossiFatema Nader

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