DOI: 10.1101/19001214Aug 5, 2019Paper

Mental Health in UK Biobank Revised

MedRxiv : the Preprint Server for Health Sciences
Katrina A S DavisMatthew Hotopf


This paper corrects and updates a paper published in BJPsych Open 2018 Mental Health in UK Biobank ( that was voluntarily retracted following the finding of errors in the coding of the variable for alcohol use disorder. Notably, the percentage of participants reaching threshold for alcohol use disorder on the Alcohol Use Disorder Identification Tool increased from 7% to 21%. This paper includes corrections and updates. Background: UK Biobank is a well-characterised cohort of over 500,000 participants that offers unique opportunities to investigate multiple diseases and risk factors. An online mental health questionnaire completed by UK Biobank participants expands the potential for research into mental disorders. Methods: An expert working group designed the questionnaire, using established measures where possible, and consulting with a service user group regarding acceptability. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and alcohol use disorders. Results: 157,366 completed online questionnaires were available b...Continue Reading

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