Mental illness and obesity among Veterans undergoing percutaneous coronary intervention: Insights from the VA CART program

Clinical Obesity
Diana P BrostowJavier Valle

Abstract

Mental illness and obesity are highly prevalent in patients with coronary disease and are frequently comorbid. While mental illness is an established risk factor for major adverse cardiac and cerebrovascular events (MACCEs), prior studies suggest improved outcomes in people with obesity. It is unknown if obesity and mental illness interact to affect cardiac outcomes or if they independently influence MACCE. We identified 55 091 patients undergoing percutaneous coronary intervention (PCI) between 2009 and 2014, using the Veterans Affairs (VA) Clinical Assessment Reporting and Tracking (CART) program. Cox methods were used to assess the risk of MACCE by weight status and psychiatric diagnosis, and assessed for interaction. Compared to normal weight status, higher weight was associated with reduced MACCE events after PCI (mean follow-up of 2 years) for both stable angina and acute coronary syndromes (ACSs; reduction of >13% in stable angina, >17% in ACS; P < 0.01 for both after adjustment). Having a non-substance abuse mental illness diagnosis increased risk of MACCE compared to patients without mental illness in stable angina over 17%; P < 0.05, but not in ACS. When analysed for interaction, obesity and mental illness did not sig...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
May 16, 2000·Archives of Internal Medicine·F LespéranceP Théroux
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Lisa F BerkmanUNKNOWN Enhancing Recovery in Coronary Heart Disease Patients Investigators (ENRICHD)
Nov 27, 2004·Psychosomatic Medicine·Jürgen BarthChristoph Herrmann-Lingen
Aug 16, 2005·Journal of the American College of Cardiology·Andrew SherwoodJames A Blumenthal
Jan 21, 2006·Journal of General Internal Medicine·Brett D ThombsRoy C Ziegelstein
Aug 11, 2006·Journal of General Internal Medicine·Ian M KronishKarina W Davidson
Jun 27, 2007·General Hospital Psychiatry·Johan OrmelRon Kessler
Nov 7, 2007·European Heart Journal·Wolfgang LindenJocelyne Leclerc
Oct 29, 2008·The American Journal of Medicine·Robert M Carney, Kenneth E Freedland
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Jul 16, 2010·JACC. Cardiovascular Interventions·Terase LancefieldUNKNOWN MIG (Melbourne Interventional Group) Registry
Feb 15, 2012·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Carla J BergJasjit S Ahluwalia
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond
Nov 2, 2013·American Heart Journal·Donald EdmondsonMatthew M Burg
Feb 18, 2014·Atherosclerosis·Nikolaos AlexopoulosPaolo Raggi
Sep 15, 2014·Journal of Clinical Psychology in Medical Settings·Cheryl BrosigKathleen Mussatto
Jan 27, 2015·Journal of Cardiopulmonary Rehabilitation and Prevention·Megan C CahillSherry L Grace
Oct 17, 2015·American Journal of Public Health·Ranak B TrivediKarin Nelson
Nov 24, 2016·Journal of Vascular Surgery·George GalyfosKonstantinos Filis
Mar 9, 2017·Journal of General Internal Medicine·Jessica Y BrelandSusan M Frayne
Apr 7, 2017·Annals of Internal Medicine·Edward YuAndrew Stokes
Jun 25, 2017·The American Journal of Cardiology·Lars JakobsenSøren P Johnsen
Jul 28, 2017·International Journal of Cardiology·Valentina TesioLorys Castelli
Sep 1, 2017·Addictive Behaviors·Alan K DavisKipling M Bohnert

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