Mental vulnerability, Helicobacter pylori, and incidence of hospital-diagnosed peptic ulcer over 28 years in a population-based cohort

Scandinavian Journal of Gastroenterology
Susan LevensteinT Jørgensen

Abstract

To examine whether mental vulnerability, an enduring personality characteristic, predicts incident hospital-diagnosed ulcer over three decades. A population-based cohort study enrolled 3365 subjects with no ulcer history, ages 30-60, in 1982-3. Mental vulnerability, Helicobacter pylori IgG antibodies, socioeconomic status, and sleep duration were determined at baseline; non-steroidal antiinflammatory drug use, smoking, leisure time physical activity, and alcohol consumption both at baseline and in 1993-4. Hospital diagnoses of incident ulcer through 2011 were detected using the Danish National Patient Registry. Ulcers were diagnosed in 166 subjects, including 83 complicated by bleeding or perforation. Age-, gender-, and socioeconomic status-adjusted associations were significant for mental vulnerability (Hazard Ratio (HR) 2.0, 95% Confidence Interval 1.4-2.8), Helicobacter pylori (HR 1.7, CI 1.2-2.3), smoking (HR 2.0, CI 1.3-3.1), heavy drinking (HR 1.6, CI 1.1-2.4), abstinence (HR 1.6, CI 1.1-2.5), non-steroidal antiinflammatory drugs (HR 2.1, CI 1.5-3.0), and sedentary lifestyle (HR 1.9, CI 1.4-2.7). Adjusted for all behavioral mediators, the HR for mental vulnerability was 1.5 (CI 1.0-2.2, p = .04). Mental vulnerability rais...Continue Reading

References

Jan 1, 1991·Scandinavian Journal of Gastroenterology·T JørgensenP Thorvaldsen
Nov 4, 1995·Lancet·J K Kiecolt-GlaserR Glaser
Sep 1, 1994·Journal of Internal Medicine·P Jess
Sep 1, 1995·Journal of Clinical Gastroenterology·S LevensteinG Lanari
Mar 1, 1996·Journal of Clinical Gastroenterology·S LevensteinS Spinella
Apr 1, 1997·Journal of Clinical Gastroenterology·S LevensteinM W Smith
Oct 27, 1997·American Journal of Surgery·G L Kauffman
Mar 28, 1998·The American Journal of Gastroenterology·N AoyamaT Chiba
Apr 29, 1998·Archives of Internal Medicine·I RäihäL Sourander
May 20, 2000·Journal of Epidemiology and Community Health·S RosenstockO Bonnevie
Dec 6, 2002·Psychotherapy and Psychosomatics·Renee D Goodwin, Murray B Stein
Oct 30, 2004·Scandinavian Journal of Gastroenterology·I Wilhelmsen, A Berstad
Feb 11, 2005·Epidemiology·Lene Falgaard EplovErik Lykke Mortensen
Jan 28, 2006·Journal of Psychosomatic Research·Lene Falgaard EplovErik Lykke Mortensen
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl
Aug 27, 2009·Alimentary Pharmacology & Therapeutics·J P Gisbert, X Calvet
Jul 21, 2010·Scandinavian Journal of Psychology·Lene Falgaard EplovErik Lykke Mortensen
Aug 19, 2010·Psychosomatic Medicine·Jean-Pierre SchusterYann Le Strat
Jun 13, 2012·The American Journal of Gastroenterology·Loren LaineCatherine Datto
Feb 28, 2014·World Journal of Gastroenterology : WJG·Katsunori IijimaTooru Shimosegawa
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Aug 12, 2014·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Cédric LemogneSilla M Consoli
Aug 12, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Susan LevensteinTorben Jorgensen
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen

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