Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy

Acta Pharmaceutica Sinica. B
Caifang GaoJianxin Wang

Abstract

Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood-brain barrier (BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers. Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and glioma-targeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs. The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of menthol-modified casein nanoparticles (M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verifie...Continue Reading

Citations

Jan 16, 2020·Current Pharmaceutical Design·Joana BickerAmílcar Falcão
Dec 18, 2020·Expert Opinion on Drug Delivery·Ebrahim MostafaviThomas J Webster
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying ZhuJianxin Wang
Apr 13, 2021·International Journal of Pharmaceutics·Ruixue YinWenjun Zhang
Aug 20, 2021·Biomedical Materials·Xing HuangBing Wang

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Methods Mentioned

BETA
surgical resection
electrophoresis
dynamic light scattering
fluorescence microscopy
confocal microscopy
fluorescence
fluorescence-activated cell sorting
FACS
flow cytometry
fluorescence imaging

Software Mentioned

GraphPad
Graphpad Prism

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