MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

Immunity
Russell G Jones, Edward J Pearce

Abstract

Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to respond rapidly upon infection or tissue damage, and in turn couple these responses with intrinsic metabolic control and conditions in the tissue microenvironment. The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) is a central integrator of extracellular and intracellular growth signals and cellular metabolism and plays important roles in both innate and adaptive immune responses. This review discusses the function of mTOR signaling in the differentiation and function of tissue-resident immune cells, with focus on the role of mTOR as a metabolic sensor and its impact on metabolic regulation in innate and adaptive immune cells. We also discuss the impact of metabolic constraints in tissues on immune homeostasis and disease, and how manipulating mTOR activity with drugs such as rapamycin can modulate immunity in these contexts.

Citations

Mar 9, 2018·Medical Sciences : Open Access Journal·Rebecca S HesterbergPearlie K Epling-Burnette
Apr 18, 2018·Immunological Reviews·Takeshi InoueTomohiro Kurosaki
Apr 4, 2018·The FEBS Journal·Sarah MacPhersonJulian J Lum
Apr 21, 2018·Annual Review of Immunology·Ramon I Klein GeltinkErika L Pearce
Jan 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuanlin DingJun Yan
Feb 20, 2019·Immunology and Cell Biology·George CaputaAlanna M Cameron
Feb 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleftheria IeronymakiChristos Tsatsanis
Jul 19, 2019·Immunology·Jasneet Kaur KhalsaGopalakrishnan Aneeshkumar Arimbasseri
Jul 13, 2019·The Journal of Experimental Medicine·Blanda Di LucciaStanley Ching-Cheng Huang
Oct 8, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Xiaowei ZhuShufeng Lei
May 3, 2020·Vaccines·Patricia PereiroBeatriz Novoa
Aug 19, 2020·Journal of Animal Science·Danielle N ColemanJuan J Loor
Sep 22, 2019·Cellular & Molecular Immunology·Zhengping WeiXiang-Ping Yang
Dec 18, 2018·Frontiers in Immunology·Karin SteinbachDoron Merkler
Jun 11, 2020·Parasites & Vectors·Alba Martínez-FlórezAlhelí Rodríguez-Cortés
Jan 24, 2018·Immunology and Cell Biology·Hazel QuekTara L Roberts
Jul 10, 2018·Immune Network·Valeriya RakhmanovaJinwook Shin
Aug 3, 2019·Stem Cell Research & Therapy·Patricia Luz-CrawfordChristian Jorgensen
Nov 23, 2019·International Journal of Molecular Sciences·Petra Hillmann, Doriano Fabbro
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Hsin-Sung Yeh, Jeongsik Yong
Sep 25, 2020·Journal of Clinical Medicine·Remsha AfzalClaire E McCoy
Nov 12, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Valerio De Vita
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Klara Kubelkova, Ales Macela
Apr 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yeonjin KimTracy L Keller
Dec 20, 2019·JCI Insight·Margaret M LoweMichael D Rosenblum
Mar 3, 2020·Frontiers in Immunology·Tiago Lazzaretti FernandesMariane Tami Amano
Sep 27, 2018·Biogerontology·Serena DatoGiuseppina Rose
Mar 27, 2020·Immunological Reviews·Hongling HuangHongbo Chi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.