Mepolizumab and Benralizumab in Severe Eosinophilic Asthma: Preliminary Results of a Proteomic Study.

Lung
Lorenza VantaggiatoClaudia Landi

Abstract

Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The aim of this proteomic study was to compare serum protein profiles of patients with severe eosinophilic asthma before and after anti-IL5 or anti-IL5R therapies. Proteomic analysis highlighted 22 differently abundant spots. Among the proteins identified, CAYP1, A1AT and A2M expression was significantly modified in both groups of patients after therapies while ceruloplasmin showed a significant modification in the group of benralizumab treatment. These differentially expressed proteins could be potential biomarkers of response to mepolizumab and benralizumab treatments and need further evaluation.

References

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Citations

Jan 27, 2021·Lung·Peter V Dicpinigaitis
Feb 20, 2021·Scandinavian Journal of Immunology·Laura BergantiniElena Bargagli
Nov 12, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Claudia LandiLuca Bini
Aug 4, 2021·Molecular Diagnosis & Therapy·Laura BergantiniElena Bargagli

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