Mepolizumab effectiveness and identification of super-responders in severe asthma.

The European Respiratory Journal
Erin S HarveyPeter G Gibson

Abstract

Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population.The Australian Mepolizumab Registry (AMR) was established with an aim to assess the use, effectiveness and safety of mepolizumab for severe eosinophilic asthma in Australia.Patients (n=309) with severe eosinophilic asthma (median age 60 years, 58% female) commenced mepolizumab. They had poor symptom control (median Asthma Control Questionnaire (ACQ)-5 score of 3.4), frequent exacerbations (median three courses of oral corticosteroids (OCS) in the previous 12 months), and 47% required daily OCS. Median baseline peripheral blood eosinophil level was 590 cells·µL-1 Comorbidities were common: allergic rhinitis 63%, gastro-oesophageal reflux disease 52%, obesity 46%, nasal polyps 34%.Mepolizumab treatment reduced exacerbations requiring OCS compared with the previous year (annualised rate ratio 0.34 (95% CI 0.29-0.41); p<0.001) and hospitalisations (rate ratio 0.46 (95% CI 0.33-0.63); p<0.001). Treatment improved symptom control (median ACQ-5 reduced by 2.0 at 6 months), quality of life and lung function. Higher...Continue Reading

References

Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Robert A NathanTrudy B Pendergraft
Apr 13, 2005·Respiratory Medicine·Elizabeth F JuniperElisabeth Ståhl
Oct 18, 2005·Respiratory Medicine·Elizabeth F JuniperUNKNOWN GOAL Committee
May 16, 2008·American Journal of Respiratory and Critical Care Medicine·Pranab HaldarRuth H Green
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Mar 7, 2009·The New England Journal of Medicine·Parameswaran NairPaul M O'Byrne
Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Apr 21, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V M McDonald, P G Gibson
Dec 10, 2013·The Journal of Allergy and Clinical Immunology·Michael SchatzTmirah Haselkorn
Sep 10, 2014·The New England Journal of Medicine·Hector G OrtegaUNKNOWN MENSA Investigators
Sep 10, 2014·The New England Journal of Medicine·Elisabeth H BelUNKNOWN SIRIUS Investigators
Sep 29, 2015·The Journal of Allergy and Clinical Immunology·Patrick LefebvreAnand A Dalal
Oct 13, 2016·ERJ Open Research·Jantina C de GrootAnneke Ten Brinke
Feb 6, 2017·Pulmonary Pharmacology & Therapeutics·Guy BrusselleJames Zangrilli
Mar 13, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Tunn Ren TayMark Hew
Sep 22, 2017·The European Respiratory Journal·Juliet M FosterHelen K Reddel
Apr 21, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S A HilesP G Gibson
Oct 26, 2018·The Journal of Allergy and Clinical Immunology·Sumita KhatriHector Ortega
Oct 27, 2018·The European Respiratory Journal·Thomas BrownUNKNOWN Members of the Wessex Severe Asthma Cohort (WSAC) team:
Jan 1, 2019·Pulmonary Pharmacology & Therapeutics·Carlo LombardiGiovanni Passalacqua
Sep 2, 2019·Pulmonary Pharmacology & Therapeutics·Diego BagnascoGiovanni Passalacqua
Sep 4, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Barak PertzovMordechai Reuven Kramer
Oct 9, 2019·Expert Review of Respiratory Medicine·Marco CaminatiGianenrico Senna
Oct 14, 2019·BMC Pulmonary Medicine·Takanori NumataKazuyoshi Kuwano

❮ Previous
Next ❯

Citations

Aug 19, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Sophie WalterRichard J Harvey
Jan 30, 2021·The European Respiratory Journal·Martin KolbMarc Humbert
Oct 19, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Katrien EgerElisabeth H Bel
Feb 9, 2021·Respirology Case Reports·Vanessa M McDonaldPeter G Gibson
Feb 6, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Dennis ThomasPeter G Gibson
May 1, 2021·International Journal of Molecular Sciences·Agamemnon BakakosPetros Bakakos
Oct 16, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ling Eng TanKwong Ng
Apr 19, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Wei Chern Gavin FongRamesh J Kurukulaaratchy
Apr 23, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stefania PrincipeAnke H Maitland-van der Zee
Jun 26, 2021·Respiratory Medicine and Research·C TailléN Roche
Jun 26, 2021·Biomarkers in Medicine·Satsuki YamadaAndre Terzic
Jul 17, 2021·The Journal of Allergy and Clinical Immunology. in Practice·John W UphamUNKNOWN Delphi Panel
Sep 30, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·John BlakeyPhilip Bardin
Oct 8, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Dorian HassounLuc Colas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Lancet. Respiratory Medicine
Garry M Walsh
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Hector G OrtegaMario Castro
The Journal of Allergy and Clinical Immunology. in Practice
Maxime CormierCatherine Lemiere
© 2021 Meta ULC. All rights reserved