Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis

Biochimica Et Biophysica Acta. Molecular Cell Research
Philipp ArnoldChristoph Becker-Pauly

Abstract

The zinc-endopeptidases meprin α and meprin β are extracellular proteases involved in connective tissue homeostasis, intestinal barrier function and immunological processes. Meprins are unique among other extracellular proteases with regard to cleavage specificity and structure. Meprin α and meprin β have a strong preference for negatively charged amino acids around the scissile bond, reflected by cleavage sites identified in procollagen I, the amyloid precursor protein (APP) and the interleukin-6 receptor (IL-6R). In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin α and meprin β is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis. Based on mouse models and patient data we suggest meprins as possible key regulators in the onset and progression of fibrotic disorders, leading to severe diseases such as pulmonary hypertension. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John.

References

Mar 1, 1996·American Journal of Respiratory Cell and Molecular Biology·C DelclauxA Harf
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M TrojanowskaT Krieg
Oct 26, 2002·The Journal of Biological Chemistry·Greg P BertenshawJudith S Bond
Jun 24, 2003·Biological Chemistry·Christoph BeckerWalter Stöcker
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline M CrismanJudith S Bond
Jun 15, 2004·Journal of the American College of Cardiology·Marc HumbertMarlene Rabinovitch
Jul 14, 2004·Chest·Vallerie V McLaughlinUNKNOWN American College of Chest Physicians
Aug 19, 2004·Cellular and Molecular Life Sciences : CMLS·V DiveA Yiotakis
Dec 29, 2005·Journal of Clinical Immunology·Rashpal K BhogalConstantin A Bona
Nov 8, 2006·Protein Science : a Publication of the Protein Society·Susanna MonacoMassimo Coletta
Jan 9, 2008·The International Journal of Biochemistry & Cell Biology·Christine T N Pham
Feb 5, 2008·The International Journal of Biochemistry & Cell Biology·Tracy L Adair-Kirk, Robert M Senior
Jul 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert EferlErwin F Wagner
Sep 6, 2008·The Journal of Biological Chemistry·David A BerginNoel G McElvaney
Sep 13, 2008·The Journal of Biological Chemistry·Sanjita Banerjee, Judith S Bond
Oct 31, 2008·American Journal of Physiology. Renal Physiology·Renee E YuraJudith S Bond
Jan 13, 2009·Biochemical and Biophysical Research Communications·Christian HerzogGur P Kaushal
Sep 15, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Daniel AmbortErwin E Sterchi
May 5, 2010·Biochimica Et Biophysica Acta·Eamon P McGrealSailesh Kotecha
Jul 16, 2010·The Journal of Investigative Dermatology·Daniel KronenbergChristoph Becker-Pauly
Aug 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shuhei TsuchiyaYasuo Yamakoshi
Nov 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sanjita BanerjeeJudith S Bond
Apr 23, 2011·Expert Review of Respiratory Medicine·Stephen C Mathai, Paul M Hassoun
Jun 8, 2011·The Journal of Biological Chemistry·Tamara JeffersonChristoph Becker-Pauly
Jul 2, 2011·Growth Factors·Lukas J A C Hawinkels, Peter Ten Dijke
Jul 2, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jason L JohnsonAndrew C Newby
Aug 11, 2012·The Journal of Biological Chemistry·Jessica BienClaus U Pietrzik
Aug 18, 2012·The Journal of Biological Chemistry·Jakub KryczkaCzesław S Cierniewski
Sep 4, 2012·Cellular and Molecular Life Sciences : CMLS·Tamara JeffersonChristoph Becker-Pauly
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Joan L ArolasF Xavier Gomis-Rüth
Jan 3, 2013·EMBO Molecular Medicine·Alex KentsisSusan Kim

❮ Previous
Next ❯

Citations

Jun 16, 2019·Cellular and Molecular Life Sciences : CMLS·Franka ScharfenbergChristoph Becker-Pauly
Mar 7, 2021·Pharmaceuticals·Shurong HouDmitriy Minond
Jun 3, 2021·International Journal of Molecular Sciences·Miriam LinnertStephan Schilling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.