Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse

Frontiers in Pharmacology
Qianying LiuZong-Hui Yuan

Abstract

Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), is a synthetic antimicrobial agent widely used in China. Previous studies found that the kidney was one of the main toxic target organs of the QdNOs. However, the mechanisms underlying the kidney toxicity caused by QdNOs in vivo still remains unclear. The present study aimed to explore the molecular mechanism of kidney toxicity in mice after chronic exposure to MEQ. MEQ led to the oxidative stress, apoptosis, and mitochondrial damage in the kidney of mice. Meanwhile, MEQ upregulated Bax/Bcl-2 ratio, disrupted mitochondrial permeability transition pores, caused cytochrome c release, and a cascade activation of caspase, eventually induced apoptosis. The oxidative stress mediated by MEQ might led to mitochondria damage and apoptosis in a mitochondrial-dependent apoptotic pathway. Furthermore, upregulation of the Nrf2-Keap1 signaling pathway was also observed. Our findings revealed that the oxidative stress, mitochondrial dysfunction, and the Nrf2-Keap1 signaling pathway were associated with the kidney apoptosis induced by MEQ in vivo.

References

Nov 16, 2004·Chemical Research in Toxicology·Goutam ChowdhuryKent S Gates
Feb 12, 2005·Antioxidants & Redox Signaling·Makoto Kobayashi, Masayuki Yamamoto
Apr 11, 2007·Chemico-biological Interactions·Amaia AzquetaAdela López de Cerain
Sep 19, 2007·The Journal of Biological Chemistry·Momoko KimuraMasayuki Yamamoto
Jul 12, 2008·Molecular Carcinogenesis·Wenge Li, Ah-Ng Kong
Dec 9, 2008·Bioorganic & Medicinal Chemistry·Esther VicenteAntonio Monge
Mar 2, 2010·Chemico-biological Interactions·Xian-Ju HuangZong-Hui Yuan
Mar 3, 2010·Rapid Communications in Mass Spectrometry : RCM·Zhao-Ying LiuZong-Hui Yuan
Apr 8, 2010·Regulatory Toxicology and Pharmacology : RTP·Awais IhsanZong-hui Yuan
Nov 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Di WangLiegang Liu
Jan 27, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xu WangZong-Hui Yuan
May 21, 2011·Molecular and Cellular Biochemistry·Ting ZhangXi-Long Xiao
Sep 13, 2011·Journal of Proteome Research·Xiu-Ju ZhaoYulan Wang
Aug 10, 2012·Biochimie·Liliana Magnago PedruzziDenise Mafra
Oct 16, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Awais IhsanZong-Hui Yuan
Apr 30, 2013·Regulatory Toxicology and Pharmacology : RTP·Miao YuLiegang Liu
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Awais IhsanZonghui Yuan
Oct 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chaoming ZhangXilong Xiao
May 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Miao YuLiegang Liu
Jul 22, 2014·Journal of Applied Toxicology : JAT·Dongxu ZhaoXilong Xiao
Nov 12, 2014·Antimicrobial Agents and Chemotherapy·Chongshan DaiXilong Xiao
Aug 25, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xu WangZonghui Yuan
Sep 18, 2015·Journal of Agricultural and Food Chemistry·Lingli HuangZonghui Yuan
Jan 6, 2016·International Journal of Environmental Research and Public Health·Anthony SkipperPaul B Tchounwou
May 14, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qianying LiuZonghui Yuan
Oct 12, 2017·Frontiers in Pharmacology·Qianying LiuZonghui Yuan

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Citations

Sep 7, 2018·Frontiers in Pharmacology·Qianying LiuZonghui Yuan

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Methods Mentioned

BETA
PCR
immunoprecipitation assay
Protein Assay
MDA

Software Mentioned

Primer Express

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