Merck Frosst award lecture 1995. La conference Merck Frosst 1995. Structural studies of lipoproteins and their apolipoprotein components

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
R O Ryan

Abstract

Lipid transport processes via the circulatory system of animals are a vital function that utilizes highly specialized lipoprotein complexes. These complexes of protein and lipid impart solubility to otherwise insoluble lipids. The apoprotein components of lipoprotein complexes serve to stabilize the lipid components and modulate particle metabolism and function as ligands for receptor-mediated endocytosis of lipoproteins. We have used an insect (Manduca sexta) model system for studies of lipid transport. In this system, flight activity elicits a dramatic increase in the demand for glycerolipid fuel molecules by flight muscle tissue. These lipids are mobilized from a storage organ and transported through the hemolymph (blood) to the flight muscle by the lipoprotein, lipophorin. This system possesses the unique property that lipids are loaded onto pre-existing high density lipophorin through the action of a lipid transfer particle (LTP). LTP is a high molecular weight hemolymph component that facilitates net vectorial lipid transfer from fat body tissue to lipophorin. The increase in lipid content of the lipoprotein induces association of a low molecular weight amphipathic exchangeable apolipoprotein, apolipophorin III (apoLp-III...Continue Reading

References

Oct 1, 1992·Analytical Biochemistry·T K SinghR O Ryan
Mar 4, 1992·Biochimica Et Biophysica Acta·R A DemelD J Van der Horst
Jan 22, 1991·Biochemistry·D R BreiterH M Holden
Apr 14, 1986·Biochemical and Biophysical Research Communications·R O RyanJ H Law
Jan 1, 1985·Peptides·A M BeenakkersWil J A van Marrewijk
Sep 30, 1983·Biochemical and Biophysical Research Communications·J P Shapiro, J H Law
Oct 1, 1994·Insect Biochemistry and Molecular Biology·B J Blacklock, R O Ryan

Citations

Apr 13, 2000·Annual Review of Entomology·R O Ryan, D J Van der Horst
Nov 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gang ZhengJerry D Glickson
Jan 29, 2000·European Journal of Biochemistry·Vasanthy NarayanaswamiR O Ryan
Aug 1, 2010·Biomolecular Concepts·D J Van der Horst, Kees W Rodenburg

Related Concepts

Lipid transfer protein
Apolipophorin-II
GLTP protein, human
Metazoa
Apolipoproteins
Biochemistry
Carrier Proteins
Endocytosis
Energy Metabolism
Flight, Animal

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Related Papers

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