Mercuric chloride induced hepatotoxic and hematologic changes in rats: The protective effects of sodium selenite and vitamin E

Toxicology and Industrial Health
Meltem UzunhisarcikliHatice Bas

Abstract

This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage for 4 weeks. HgCl2-treated groups had significantly higher white blood cell and thrombocyte counts than the control group. Serum activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl-transferase, and lactate dehydrogenase significantly increased and serum levels of total protein, albumin, triglyceride, total cholesterol, and low-density lipoprotein cholesterol significantly decreased in the HgCl2-treated groups compared with control group. Malondialdehyde level significantly increased and superoxide dismutase, catalase, and glutathione peroxidase activities decreased in liver tissue of HgCl2-treated rats. Also, HgCl2 exposure resulted in histopathological changes. Supplementation of Na2SeO3 and/or vitamin E provided partial protection in hematological and biochemical parameters that were altered by HgCl2 As a result, Na2SeO3 and/or vitamin E significantly reduced HgCl...Continue Reading

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Citations

Apr 2, 2016·Regulatory Toxicology and Pharmacology : RTP·Qin WuJie Liu
Mar 18, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Sunny O AbarikwuGoodluck Agbam
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Nov 21, 2019·Environmental Science and Pollution Research International·Meltem Uzunhisarcikli, Ayse Aslanturk
Jan 5, 2021·Environmental Science and Pollution Research International·Shimaa S RamadanAhmed E Abdel Moneim
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak

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Methods Mentioned

BETA
MDA
light microscopy

Software Mentioned

Statistical Package for the Social Sciences

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