Mercury distribution and concentration in rats fed powdered dental amalgam

Archives of Oral Biology
Keun Bae SongHo Keun Kwon

Abstract

The aim was to evaluate the distribution and elimination of mercury in the tissues of rats exposed to powdered dental amalgam. The study comprised of three groups: the first (A) was an unexposed control, the second (B) was fed 8.3mg of powdered amalgam weekly for 12 weeks, and the third (C) was fed 25.0mg of powdered amalgam weekly for 4 weeks followed by either a 4- or 8-week period of non-exposure. The total amount of amalgam administered in each of the latter two groups was 0.1g. Animals were killed at 4, 8 and 12 weeks, and their kidneys, liver and brains were removed. Mercury present in tissues from one side was analysed by cold-vapour atomic absorption spectrometry; tissues from the other side were stained autometallographically. No mercury was detected in any tissue of control group A. In group B, the mercury concentration in the kidneys was significantly higher than that of the control, whereas in group C, the mercury concentration in both the liver and kidneys decreased significantly during the period of non-exposure. Mercury was not detected in brain tissue from any group. The light-microscopic findings were in agreement with the quantitative results. Mercury grains were most common in the renal cortex, especially in ...Continue Reading

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