Mercury (Hg2+) suppression of potassium currents of outer hair cells

Neurotoxicology and Teratology
G-H LiangE J Moore

Abstract

The heavy metal mercury (Hg(2+)) is an insidious environmental pollutant that causes toxic effects on sensory systems. It is well known that the group IIB divalent cation Hg(2+) is an inhibitor of the group I monovalent potassium (K(+)) cation pore-forming channel in several biological preparations. Here, we used the whole cell patch clamp technique on freshly isolated outer hair cells (OHCs) of the guinea pig cochlea to record outward K(+) currents and inward K(+) currents treated with mercuric chloride (HgCl(2)). HgCl(2) affected K(+) currents in a voltage- and dose-dependent manner. The effects of HgCl(2) at 1.0-100 microM are more pronounced on onset peak current than on steady-state end current. HgCl(2) depolarized also the resting membrane potential. Although the effect of HgCl(2) at 1.0 microM was partially washed out over several minutes, the effects at 10 and 100 microM were irreversible to washout. Since K(+) channels of OHCs are targets for HgCl(2) ototoxicity, this may lead to auditory transduction problems, including a loss in hearing sensitivity. A better understanding of fundamental mechanisms underlying K(+) channelopathies in OHCs due to HgCl(2) poisoning may lead to better preventive or therapeutic agents.

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Citations

Oct 15, 2013·BMC Genomics·Matthew K McElweeJonathan H Freedman
Jan 6, 2010·International Journal of Environmental Research and Public Health·Dragan R MilićevićSrdan M Stefanović
Feb 22, 2014·BMC Physiology·Calvin WuErnest J Moore
Jul 9, 2004·Toxicology and Applied Pharmacology·S Allen Counter, Leo H Buchanan
Sep 4, 2012·Aquatic Toxicology·K FaucherC Adam-Guillermin
Apr 1, 2017·Journal of the Association for Research in Otolaryngology : JARO·Sarah E WolfWilliam J Buchser
Jun 26, 2012·Cadernos de saúde pública·Ana Cristina Hiromi HoshinoVolney Magalhães Câmara
Jul 15, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ji Woong AhnSeung Cheol Ahn
Apr 26, 2006·Acta Physiologica·L LacinováF Hofmann
Dec 17, 2008·International Journal of Audiology·Janet A Rothwell, Paul J Boyd
Dec 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Bohumila TarabováL'ubica Lacinová
Jun 21, 2019·Oxidative Medicine and Cellular Longevity·Shou-Sen HuXiang-Zhen Kong
May 5, 2016·Neurotoxicity Research·Jerome A Roth, Richard Salvi
Oct 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Aiqing LiZhen Hong
Jun 29, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Giuseppe MontalbanoBasilio Randazzo

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