PMID: 9445964Jan 1, 1997Paper

Merkel cell carcinoma: follow-up of 10 patients. Current diagnosis and therapy

Langenbecks Archiv für Chirurgie
A HauschildE Christophers

Abstract

Merkel cell carcinoma (MCC) is a rare neoplasm of the skin predominantly found on the head and extremities. Clinically MCC presents as a rapidly growing red or violaceous, dome-shaped, solitary tumor. The clinical and histological diagnosis of MCC remains difficult. Distinction from poorly differentiated small cell primary tumors or metastasis requires immunohistochemical analysis and-if available-electron-microscopic studies. We report on the follow-up of 10 patients with MCC treated in the past 6 years at our department. In nine patients the tumors were completely removable; in one patient with a large primary tumor of the upper lip no histologically proven complete excision could be performed. After a median follow-up of 42 months, local recurrence or lymph node involvement was observed in three patients. Two patients died following disseminated metastases, one elderly patient due to cardiac insufficiency. Our observations demonstrate that MCC is a potentially aggressive cutaneous tumor. Adequate primary surgical and adjuvant therapy as well as careful follow-up are mandatory.

Citations

May 31, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R Salvador AlonsoR de Crevoisier
Jun 6, 2007·Hematology/oncology Clinics of North America·Vy DinhNiramol Savaraj
May 15, 2009·The British Journal of Dermatology·E Güler-NizamT K Eigentler

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