Merkel cell carcinoma

Nature Reviews. Disease Primers
Jürgen C BeckerPaul Nghiem

Abstract

Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with neuroendocrine features. MCC pathogenesis is associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet light (UV), which can cause a characteristic pattern of multiple DNA mutations. Notably, in the Northern hemisphere, the majority of MCC cases are of viral aetiology; by contrast, in areas with high UV exposure, UV-mediated carcinogenesis is predominant. The two aetiologies share similar clinical, histopathological and prognostic characteristics. MCC presents with a solitary cutaneous or subcutaneous nodule, most frequently in sun-exposed areas. In fact, UV exposure is probably involved in both viral-mediated and non-viral-mediated carcinogenesis, by contributing to immunosuppression or DNA damage, respectively. Confirmation of diagnosis relies on analyses of histological features and immunological marker expression profiles of the lesion. At primary diagnosis, loco-regional metastases are already present in ∼30% of patients. Excision of the tumour is the first-line therapy; if not feasible, radiotherapy can often effectively control the disease. Chemotherapy was the only alternative in advanced-stage or refrac...Continue Reading

References

Jan 1, 1972·Archives of Dermatology·C Toker
Nov 12, 1998·Journal of the American Academy of Dermatology·M V IacoccaJ Bhawan
Dec 28, 1999·Transplantation·I Penn, M R First
Mar 4, 2000·The American Journal of Dermatopathology·H A BrownT Woo
Mar 29, 2000·The British Journal of Dermatology·P ZiprinR D Rosin
Jul 21, 2001·Journal of the American Academy of Dermatology·K P An, D Ratner
Feb 21, 2002·Lancet·Eric A EngelsRobert W Miller
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Susanne PoppPetra Boukamp
Jun 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·L GROSS
Oct 25, 2003·Journal of the American Academy of Dermatology·Maria Agelli, Limin X Clegg
Dec 22, 2004·Journal of Surgical Oncology·Nicole C Hodgson
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J AllenDaniel G Coit
Apr 13, 2005·Journal of Occupational Health·Sheng-Yow HoHow-Ran Guo
Aug 10, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Regan A HowardLois B Travis
Feb 9, 2007·Journal of Virology·Tobias AllanderBjörn Andersson
May 4, 2007·The Journal of Investigative Dermatology·Roland HoubenJuergen C Becker
May 24, 2007·Cancer·Christopher K BichakjianSandra L Wong
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Feb 19, 2008·Journal of the American Academy of Dermatology·Michelle HeathPaul Nghiem
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Masahiro ShudaYuan Chang
Nov 13, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jürgen C BeckerRoland Houben
Jun 6, 2009·International Journal of Cancer. Journal International Du Cancer·Yanis L TolstovPatrick S Moore
Jun 23, 2009·Science·Stephen M MaricichHuda Y Zoghbi
Jul 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jayme B StokesElihu J Ledesma
Sep 15, 2009·PLoS Pathogens·Diana V PastranaChristopher B Buck
Mar 6, 2010·Immunology·John S YiAllan J Zajac
Apr 27, 2010·Advances in Anatomic Pathology·Kenneth B Calder, Bruce R Smoller
Apr 29, 2010·Journal of the National Cancer Institute·Jeanette KaaeMads Melbye
Jun 15, 2010·Cell Host & Microbe·Rachel M SchowalterChristopher B Buck
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly G PaulsonPaul Nghiem
May 13, 2011·The Journal of Investigative Dermatology·David SchramaJürgen C Becker
Jun 24, 2011·The Journal of Investigative Dermatology·Heather M AmesTheodora S Ross
Jun 30, 2011·The British Journal of Dermatology·J GirschikL Fritschi

❮ Previous
Next ❯

Citations

Mar 15, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stephan GrabbeJürgen C Becker
Mar 21, 2018·Head and Neck Pathology·Michael T Tetzlaff, Priyadharsini Nagarajan
Aug 7, 2018·The American Journal of Surgical Pathology·Mohammed T LiloRobert E LeBlanc
Nov 6, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Selma Ugurel
Feb 7, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul NghiemSuzanne L Topalian
Jan 30, 2019·Current Opinion in Oncology·Véronique Del Marmol, Celeste Lebbé
Feb 26, 2019·The Journal of Dermatology·Shiho HanaiYoshiki Tokura
Feb 28, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·R M LucasR E Neale
Mar 13, 2019·The Journal of Dermatology·Hidehiko MiyazawaYoshiki Tokura
Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kateryna V LaikovaAnatoly V Kubyshkin
May 6, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jürgen C BeckerCornelia Mauch
Jan 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Donglim Esther ParkJames A DeCaprio
Sep 5, 2019·JAMA Dermatology·Paul Nghiem, Song Youn Park
Aug 31, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P TerheydenE A Langan
Mar 26, 2019·The American Journal of Dermatopathology·Andrea SagginiCarlo Cota
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Balint CsobozUgo Moens
Jan 24, 2020·Current Opinion in Oncology·Mahtab SamimiAntoine Touze
Dec 7, 2019·The American Journal of Dermatopathology·Angel Fernandez-FloresEduardo Fonseca
Jun 13, 2018·The American Journal of Dermatopathology·Andrew SirefBonnie Balzer
Jul 25, 2018·Oncotarget·Emil ChteinbergAxel Zur Hausen
Feb 6, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·T GambichlerJ C Becker
Mar 3, 2020·Dermatologic Therapy·Mohamad GoldustStephan Grabbe
Jun 13, 2020·International Journal of Dermatology·Juan Torre-CastroCarlos Santonja
Sep 22, 2020·Expert Opinion on Biological Therapy·Gerhard Hamilton
Mar 2, 2019·Dermatology and Therapy·Alessia VillaniMassimiliano Scalvenzi
Jun 16, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thibault KervarrecSerge Guyétant
Nov 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gensuke AkaikeFatemeh Behnia
Nov 21, 2019·International Journal of Molecular Sciences·Artem SmirnovEleonora Candi
Aug 7, 2020·Asia-Pacific Journal of Clinical Oncology·David L KokGerald Fogarty
Jun 29, 2018·International Journal of Molecular Sciences·Aelita KonstatinellUgo Moens
May 26, 2018·Targeted Oncology·Matt Shirley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.