Merkel Cell Polyomavirus Is Associated with Anal Infections in Men Who Have Sex with Men

Microorganisms
Nunzia ZanottaManola Comar

Abstract

Viral infections of the anal/rectal tract of men who have sex with men (MSM) have been poorly studied. In total, 158 swab samples (81 anal/rectal, 65 throat/oral and 12 urethral) were collected from 126 MSM. DNA was isolated and subjected to real-time PCR assays for the detection of the sexually transmitted (ST) pathogens Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasmas ssp, human papillomavirus (HPV) and six human polyomaviruses (HPyVs; JCPyV, BKPyV, Merkel cell PyV⁻MCPyV-, HPyV-6, HPyV-7 and HPyV-9). C. trachomatis (31/126, 24.6%) and M. genitalium (30/126, 23.8%) were the most frequently detected ST pathogens. Thirty-one/126 (24.6%) patients were positive for at least one HPyV. The significantly (p < 0.05) prevalent HPyV in the anal tract was MCPyV, which was amplified in 27/81 (33.3%) samples, followed by HPyV-6, which was amplified in 6/81 (7.4%) swabs. Coinfections with MCPyV and C. trachomatis or Mycoplasmas were found in 4/21 (19.0%) and 5/21 (23.8%) anal/rectal swabs, respectively. Three/4 MCPyV-C. trachomatis coinfected patients were symptomatic. Based on the high prevalence of MCPyV in the anal/rectal swabs from MSM patients and on the well-known oncogenic properties of MCPyV, sexual transmission and poss...Continue Reading

References

Aug 15, 1990·International Journal of Cancer. Journal International Du Cancer·D CaussyS Z Wiktor
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J M PalefskyT M Darragh
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Apr 23, 2008·The Journal of Infectious Diseases·Alan NyitrayAnna R Giuliano
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Kishor BhatiaLeona W Ayers
Oct 1, 2009·Emerging Infectious Diseases·Ulrike WielandHerbert Pfister
Jun 15, 2010·Cell Host & Microbe·Rachel M SchowalterChristopher B Buck
Aug 23, 2012·PloS One·Manola ComarMauro Tognon
Nov 30, 2013·The Urologic Clinics of North America·Bassel G Bachir, Keith Jarvi
Feb 22, 2014·Journal of Lower Genital Tract Disease·Victor Hugo MeloJoel Michael Palefsky
Sep 12, 2014·Cancer Chemotherapy and Pharmacology·Paola Simona RavendaMaria Giulia Zampino
Dec 3, 2014·Obstetrics and Gynecology Clinics of North America·Amy P Murtha, James M Edwards
Feb 5, 2016·World Journal of Gastrointestinal Surgery·Ira L Leeds, Sandy H Fang
Feb 26, 2016·The Journal of Infectious Diseases·Yumiko HashidaMasanori Daibata
Mar 26, 2016·Sexually Transmitted Infections·Pratt Kolia-DiafoukaUNKNOWN HARP Study Group
Aug 23, 2016·PloS One·Chang Hun LeeHong Je Cho
Oct 12, 2016·Microbiology Spectrum·Linda Cook
Nov 20, 2016·Journal of Cellular Physiology·John Charles RotondoFernanda Martini
Jan 4, 2017·Journal of the American Academy of Dermatology·Khang D NguyenRichard C Wang
Feb 9, 2017·Canadian Journal of Microbiology·Soumen Bhattacharjee, Sutanuka Chattaraj
Mar 28, 2017·Virology·Tarik GheitMassimo Tommasino
Apr 4, 2017·International Journal of Cancer. Journal International Du Cancer·Catherine de MartelSilvia Franceschi
Jun 22, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ugo MoensChris Lauber
Feb 15, 2018·Sexually Transmitted Infections·Lukas BaumannNicola Low
Apr 24, 2018·Molecular Phylogenetics and Evolution·Carolina TorresViviana Andrea Mbayed
May 26, 2018·Journal of Medical Virology·Vitaly SmelovJoakim Dillner
Jun 2, 2018·Environmental Pollution·Maria DolciSerena Delbue
Oct 24, 2018·PloS One·Sergio KammingaHans L Zaaijer
Nov 9, 2018·The Journal of General Virology·Aboud Kourieh For The Split Study Group

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Datasets Mentioned

BETA
MG241580.1
MG241582.1
LC097004.1
KX827417.1

Methods Mentioned

BETA
PCR
genotyping
Assay
biopsy

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