Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs

Virus Genes
Michiko MatsushitaKazuhiko Hayashi

Abstract

Most of merkel cell carcinomas (MCC), a rare, aggressive skin cancer with neuroendocrine features, harbor merkel cell polyomavirus (MCPyV). Seroepidemiological studies suggested high prevalence of MCPyV in the human population. More than ten sequence data on MCPyV strains in Japan have been available, whereas most sequence data were detected from patients living in Europe or European ancestry. Analysis of nine almost complete and 19 partial sequences from two oncogenes, small T antigen (ST) and large T antigen (LT) genomes obtained from 32 Japanese MCPyV-infected MCC revealed that each Japanese MCPyV-infected MCC harbored a specific MCPyV strain with some synonymous or, silent mutations and stop codons or deletions, but functional domains of T antigen had no amino acid changes. All stop codons were localized after retinoblastoma protein-binding domain. These Japanese MCPyV strains were very closely interrelated to themselves and a consensus sequence of Japanese strain was generated. Phylogenetic analysis of our nine sequences and 70 other sequences for ST and LT gene registered in GenBank indicated that Japanese or Asian MCPyV strains formed distinct clades from Caucasian clade, and phylogenetic tree of our nine and 75 other se...Continue Reading

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Citations

Dec 31, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew G MinerSteven D Billings
Dec 31, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takeshi IwasakiKazuhiko Hayashi
Dec 15, 2017·Virology : Research and Treatment·Camila Freze BaezSerena Delbue
Mar 3, 2020·Frontiers in Molecular Biosciences·Reety AroraSudhir Krishna
Jul 9, 2020·Cancers·Valeria PietropaoloUgo Moens
Nov 25, 2020·Annual Review of Pathology·James A DeCaprio

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