Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice

Cancer Research
Monique E VerhaegenAndrzej A Dlugosz

Abstract

Merkel cell carcinoma (MCC) tumor cells express several markers detected in normal Merkel cells, a nonproliferative population of neuroendocrine cells that arise from epidermis. MCCs frequently contain Merkel cell polyomavirus (MCPyV) DNA and express viral transforming antigens, sT and tLT, but the role of these putative oncogenes in MCC development, and this tumor's cell of origin, are unknown. Using a panel of preterm transgenic mice, we show that epidermis-targeted coexpression of sT and the cell fate-determinant atonal bHLH transcription factor 1 (ATOH1) leads to development of widespread cellular aggregates, with histology and marker expression mimicking that of human intraepidermal MCC. The MCC-like tumor phenotype was dependent on the FBXW7-binding domain of sT, but not the sT-PP2A binding domain. Coexpression of MCPyV tLT did not appreciably alter the phenotype driven by either sT or sT combined with ATOH1. MCPyV sT, when coexpressed with ATOH1, is thus sufficient to initiate development of epidermis-derived MCC-like tumors in mice. Cancer Res; 77(12); 3151-7. ©2017 AACR.

References

Sep 29, 2009·Developmental Biology·Kristin M MorrisonStephen M Maricich
Sep 30, 2009·The Journal of Cell Biology·Alexandra Van KeymeulenCédric Blanpain
Mar 18, 2011·International Journal of Cancer. Journal International Du Cancer·Roland HoubenDavid Schrama
Sep 29, 2011·Annual Review of Pathology·Yuan Chang, Patrick S Moore
Sep 22, 2012·Annual Review of Microbiology·Ping AnJames M Pipas
Mar 12, 2013·Nature Reviews. Microbiology·James A DeCaprio, Robert L Garcea
Nov 13, 2013·The Journal of Investigative Dermatology·Masahiro ShudaPatrick S Moore
May 9, 2014·The International Journal of Biochemistry & Cell Biology·Piotr Czapiewski, Wojciech Biernat
Sep 6, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Ata S Moshiri, Paul Nghiem
Oct 15, 2014·The Journal of Investigative Dermatology·Monique E VerhaegenAndrzej A Dlugosz
Jan 28, 2015·The Journal of Cell Biology·Margaret C WrightStephen M Maricich
Feb 15, 2015·Current Opinion in Virology·Justin A WendzickiYuan Chang

❮ Previous
Next ❯

Citations

Jan 13, 2018·Oncogene·J C SunshineJ Choi
Oct 27, 2017·Nature Reviews. Disease Primers·Jürgen C BeckerPaul Nghiem
Jan 30, 2019·Current Opinion in Oncology·Véronique Del Marmol, Celeste Lebbé
Jun 11, 2019·International Journal of Cancer. Journal International Du Cancer·Satendra KumarWeng-Onn Lui
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexis HaroldMasahiro Shuda
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Balint CsobozUgo Moens
Aug 25, 2018·Oncotarget·Kashif RasheedUgo Moens
Jul 1, 2020·Annual Review of Virology·Wei Liu, Jianxin You
Apr 27, 2018·Frontiers in Microbiology·Celestino VelásquezMasahiro Shuda
Jun 16, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thibault KervarrecSerge Guyétant
Feb 2, 2020·Scientific Reports·Magali BoyerCatherine Alix-Panabières
Jun 29, 2018·International Journal of Molecular Sciences·Aelita KonstatinellUgo Moens
Oct 24, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thibault KervarrecSerge Guyétant
Oct 6, 2018·Nature Reviews. Clinical Oncology·Paul W HarmsUNKNOWN International Workshop on Merkel Cell Carcinoma Research (IWMCC) Working Group
Jan 31, 2020·Virus Genes·Danyal TahseenStephen K Tyring
Sep 10, 2020·Journal of Clinical Medicine·Taxiarchis Konstantinos NikolouzakisJohn Tsiaoussis
Apr 17, 2020·Cancers·Magali BoyerCatherine Alix-Panabières
Jul 9, 2020·Cancers·Valeria PietropaoloUgo Moens
Dec 9, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aric ColungaPaul Nghiem
Nov 25, 2020·Annual Review of Pathology·James A DeCaprio
Jan 26, 2020·The Journal of Investigative Dermatology·Frances M WalockoRajiv I Nijhawan
Jul 3, 2021·Biomedicines·Elena DellambraLuca Fania
Aug 1, 2021·Virchows Archiv : an International Journal of Pathology·Benjamin SundqvistVirve Koljonen
Sep 3, 2021·The Journal of Investigative Dermatology·Paul W HarmsArul M Chinnaiyan
Oct 2, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul W HarmsAndrzej A Dlugosz
Nov 5, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kervarrec Thibault

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.