PMID: 8599471Dec 1, 1995Paper

Merkel cells in nevus sebaceus. An immunohistochemical study

The American Journal of Dermatopathology
T Schulz, W Hartschuh

Abstract

Nevus sebaceus, considered to be a hamartoma, is known to develop several secondary hyperplastic and neoplastic proliferations. By the use of immunohistochemical studies, we were able to describe a sometimes very striking increase of Merkel cells in nine of 19 nevi sebacei. Only nevi sebacei that formed follicular germ structures and trichoblastomas showed a Merkel cell hyperplasia. In the hyperplastic epidermis of some cases a slight hyperplasia of singular Merkel cells was observed. In foci with follicular germs and trichoblastomas, however, the Merkel cells were much more abundant and sometimes arranged in clusters. Merkel cell hyperplasia is likely to represent another facet of hamartomatous hyperplasia in nevi sebacei. Our observation that trichoblastomas in nevus sebaceus possess, as a rule, hyperplasia of Merkel cells, might be an additional aid to distinguish these tumors from basal cell carcinomas, which are usually devoid of Merkel cells. Furthermore, our findings are a hint that development of follicular germs and trichoblastomas in nevi sebacei may be promoted by Merkel cells.

Citations

Oct 23, 1997·The American Journal of Dermatopathology·G CollinaR A Fano
Aug 19, 2000·The American Journal of Dermatopathology·E Abesamis-CubillanP E LeBoit
Jul 26, 2002·The American Journal of Dermatopathology·Christophe PerrinJean-Francois Michiels
Apr 21, 2006·The American Journal of Dermatopathology·Dmitry V KazakovMichal Michal
Apr 7, 2007·The American Journal of Dermatopathology·Doina IvanVictor G Prieto
Sep 23, 2008·The American Journal of Dermatopathology·Wei SuClay J Cockerell
Nov 5, 2010·The American Journal of Dermatopathology·Maxime BattistellaBernard Cribier
Jun 11, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Muba TaherRichard Bennett
Oct 22, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rafael AguayoRosa M Martí
Aug 13, 2015·Journal of Cutaneous Pathology·Ana María Molina-RuizLeo Schärer
Mar 29, 2003·Veterinary Dermatology·Giorgio BagnascoFrancesca Abramo
Feb 5, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Katharina Wiedemeyer, Wolfgang Hartschuh
Nov 7, 2008·Journal of Cutaneous Pathology·Luis RequenaHeinz Kutzner
May 15, 2010·International Journal of Dermatology·Ichiro KurokawaHitoshi Mizutani
Mar 4, 2015·Journal of Cutaneous Pathology·Ana M Molina-RuizArno Rütten
Apr 7, 2007·Journal of the American Academy of Dermatology·Nicholas Boulais, Laurent Misery
Sep 28, 2016·The American Journal of Dermatopathology·Eman Aljufairi, Fayek Alhilli
Nov 7, 2002·Anatomical Science International·Tamiko Tachibana, Tokio Nawa
Jun 26, 2018·International Journal of Surgical Pathology·Cem LeblebiciGülben Erdem Huq
Dec 31, 1998·Journal of Cutaneous Pathology·K HashimotoY Narisawa
Nov 22, 2018·Archives of Dermatological Research·Yutaka NarisawaKotaro Nagase
Dec 9, 2020·The American Journal of Dermatopathology·Lamiaa HamieJag Bhawan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.