Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections

Pharmacotherapy
Blair CapitanoDavid L Paterson

Abstract

The treatment of gram-negative infection of the central nervous system (CNS) presents a clinical challenge due to antibiotic resistance and difficulties with penetration into the cerebrospinal fluid (CSF). Two patients with gram-negative CNS infections were treated successfully with high-dose, prolonged infusions of meropenem. The CSF meropenem concentrations exceeded the minimum inhibitory concentration of the pathogen for virtually the entire dosing interval in both cases. Our experience demonstrates that dosage modification to maximize pharmacodynamic targets and bactericidal activity may be practically applied to optimize antibiotic treatment for difficult-to-treat CNS infections.

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Citations

Sep 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson
Mar 3, 2010·Expert Review of Anti-infective Therapy·David Felipe BriceñoMaría Virginia Villegas
Oct 3, 2006·Expert Review of Anti-infective Therapy·Paolo Grossi, Daniela Dalla Gasperina
Dec 19, 2015·Expert Review of Clinical Pharmacology·Marguerite L MonogueDavid P Nicolau
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Effie L GillespieDavid P Nicolau
Jan 15, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ken EguchiMitsuo Kaku
Jun 9, 2009·Médecine et maladies infectieuses·F Van Bambeke, P M Tulkens
Mar 17, 2007·Neuroscience Letters·Joseph OommenRobert S Fisher
Jan 30, 2008·Pharmacotherapy·Anthony M NicasioDavid P Nicolau
Feb 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelJoseph R Zunt
May 3, 2007·The Annals of Pharmacotherapy·Anthony M NicasioDavid P Nicolau
Jul 25, 2019·European Journal of Clinical Pharmacology·Ana Isabel Idoate GrijalbaJean-Baptiste Woillard
May 30, 2013·The Annals of Pharmacotherapy·Wendy J LamMelvin P Weinstein
Jan 23, 2021·Pharmacotherapy·Andrew J FratoniJoseph L Kuti

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