Meropenem and Amikacin for Management of Post-Neurosurgical Infections from Acinetobacter baumannii

Surgical Infections
Qiang HuangWenguo Wang

Abstract

Background: Intra-cranial infection with Acinetobacter baumannii is a tough problem because of the presence of multi-resistance and poor drug penetration through the blood-brain barrier. Such intra-cranial infections can lead to serious complications and death. We retrospectively analyzed the culture results and clinical characteristics of patients with intra-cranial infections in our hospital and suggested intravenous (IV) meropenem and intra-thecal (IT) amikacin therapy may be effective in the management of A. baumannii infection. Case presentation: We reported four cases of post-neuro-surgical A. baumannii intra-cranial infection whose clinical futures were high fever and consciousness disturbance. Our patients were treated successfully with IV meropenem and IT amikacin. Conclusion: We presented our cases of pandrug-resistant A. baumannii intra-cranial infection that was managed successfully with a systemic provision of IV meropenem and IT amikacin. Therefore, these cases exemplify that systemic administration of IV meropenem and IT amikacin can be a good therapeutic option against A. baumannii intra-cranial infection when colistin is not available.

References

Oct 13, 2004·Clinical Therapeutics·Holly M MattoesDavid P Nicolau
Apr 23, 2005·The Journal of Infection·Sofia K KasiakouMatthew E Falagas
Sep 13, 2005·British Journal of Neurosurgery·Mahmut AkyuzRecai Tuncer
Jun 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelUNKNOWN Infectious Diseases Society of America
Nov 22, 2008·The Lancet Infectious Diseases·Drosos E Karageorgopoulos, Matthew E Falagas
Jan 15, 2010·The New England Journal of Medicine·Diederik van de BeekAllan R Tunkel
Jul 9, 2010·BMC Infectious Diseases·Lemuel L DentRobert B Hulette
Jul 8, 2016·Annals of Biomedical Engineering·K TangenA A Linninger

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