Meropenem-vaborbactam for the treatment of complicated urinary tract infections including acute pyelonephritis

Expert Opinion on Pharmacotherapy
Gary Wu, Eunah Cheon

Abstract

Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carbapenemases (KPC), in addition to other class A and class C beta-lactamases. The US Food and Drug Administration has recently approved meropenem-vaborbactam for the treatment of adult patients with complicated urinary tract infections including acute pyelonephritis. Areas covered: A PubMed search was performed to gather the most current and relevant articles regarding meropenem-vaborbactam. In this review the authors discuss the chemistry, mechanism of action, pharmacokinetics, pharmacodynamics, antimicrobial spectrum, and efficacy and safety of meropenem-vaborbactam for the treatment of complicated urinary tract infections including acute pyelonephritis Expert opinion: Although meropenem-vaborbactam is approved for treatment for complicated urinary tract infections including acute pyelonephritis, it is unlikely, at this point, to be utilized widely beyond cases that are caused by KPC-producing Enterobacteriaceae. It may also b...Continue Reading

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Citations

Dec 27, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·D A BeshnovaA M Egorov
Dec 15, 2019·Biomolecules·Alexey EgorovAlexander Veselovsky
Oct 22, 2020·Research : a Science Partner Journal·Zifang ShangWei Huang
Feb 15, 2021·International Journal of Biological Macromolecules·Sourya BhattacharyaSaugata Hazra

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