Merozoite surface protein 4/5 provides protection against lethal challenge with a heterologous malaria parasite strain

Infection and Immunity
M W GoschnickR L Coppel

Abstract

Immunization with merozoite surface protein 4/5 (MSP4/5), the murine malaria homologue of Plasmodium falciparum MSP4 and MSP5, has been shown to protect mice against challenge by parasites expressing the homologous form of the protein. The gene encoding MSP4/5 was sequenced from a number of Plasmodium yoelii isolates in order to assess the level of polymorphism in the protein. The gene was found to be highly conserved among the 13 P. yoelii isolates sequenced, even though many of the same isolates showed pronounced variability in their MSP1(19) sequences. Nonsynonymous mutations were detected only for the isolates Plasmodium yoelii nigeriensis N67 and Plasmodium yoelii killicki 193L and 194ZZ. Immunization and challenge of BALB/c mice showed that the heterologous MSP4/5 proteins were able to confer a level of protection against lethal Plasmodium yoelii yoelii YM challenge infection similar to that induced by immunization with the homologous MSP4/5 protein. To explore the limits of heterologous protection, mice were immunized with recombinant MSP4/5 protein from Plasmodium berghei ANKA and Plasmodium chabaudi adami DS and challenged with P. y. yoelii YM. Interestingly, significant protection was afforded by P. berghei ANKA MSP4/...Continue Reading

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Citations

May 10, 2005·Molecular and Biochemical Parasitology·Hannah E J PolsonShirley Longacre
Jan 30, 2014·Parasites & Vectors·Rodney Hull, Zodwa Dlamini
Apr 11, 2009·Trends in Parasitology·Ross L Coppel
Aug 21, 2009·Parasite Immunology·K J Limbach, T L Richie
Jan 28, 2017·Immunotherapy·Manuel E PatarroyoJorge Aza-Conde
Jul 16, 2014·Molecular & Cellular Proteomics : MCP·Olivia C FinneyRuobing Wang
Apr 27, 2019·Frontiers in Immunology·Yenni YusufShigeto Yoshida
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dodie S PouniotisMagdalena Plebanski
Jul 25, 2019·Journal of Proteome Research·Melanie J ShearsPhotini Sinnis

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