Mesalazine and/or Lactobacillus casei in preventing recurrence of symptomatic uncomplicated diverticular disease of the colon: a prospective, randomized, open-label study

Journal of Clinical Gastroenterology
A TursiWalter Elisei

Abstract

To investigate the effectiveness and safety of mesalazine, with or without Lactobacillus casei, in preventing recurrence of symptomatic diverticular disease of the colon. Both mesalazine and probiotics showed recently their effectiveness in obtaining remission of symptomatic uncomplicated diverticular disease of the colon. Consistent data are not available on the optimal therapy to prevent recurrence of symptomatic diverticular disease of the colon. Multicenter, prospective, randomized, open-label study. Ninety consecutive patients (36 men, 54 women, mean age 67.5 y, range 39 to 84 y), previously affected by symptomatic uncomplicated diverticular disease of the colon (remission obtained with rifaximin 800 mg/d plus mesalazine 2.4 g/d for 10 d, followed by mesalazine 1.6 g/d for 8 wk), were enrolled in a 12-month follow-up. The following symptoms were assessed at entry and through follow-up by using a quantitative scale: (1) constipation, (2) diarrhea, (3) abdominal pain, (4) rectal bleeding, and (5) mucus with the stools. After recruitment, the patients were randomly assigned to one of the following 3 groups: mesalazine 1.6 g/d (group M), L. casei DG 16 billion/d for 15 d/mo (group L); mesalazine 1.6 g/d+L. casei DG 16 billion/...Continue Reading

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Citations

Oct 23, 2008·International Journal of Colorectal Disease·Antonio TursiFabio Aiello
May 12, 2012·International Journal of Colorectal Disease·Cagdas UnlüMarja A Boermeester
Feb 1, 2011·Internal and Emergency Medicine·Luigi GattaCarmelo Scarpignato
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Feb 6, 2010·World Journal of Gastrointestinal Pharmacology and Therapeutics·Antonio Tursi
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Jan 12, 2011·Digestive Diseases and Sciences·Luca ElliLuca Piodi
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Mar 19, 2008·Journal of Clinical Gastroenterology·Antonio TursiFabio Aiello
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