Mesangiolytic glomerulopathy in severe congestive heart failure

Kidney International
H YoshidaS Sasayama

Abstract

To study the glomerular morphological abnormalities in congestive heart failure (CHF), we analyzed 27 autopsy cases without other causes of renal disease. Their mean age was 59 years, and they showed mild prerenal azotemia. They had generally been treated with digitalis and diuretics, and a few of them with captopril or nifedipine. The abnormal glomerular findings of enlargement, hyperemia, and mesangial thickening were observed at high frequencies (61%, 64%, and 57%, respectively). They characteristically showed mesangiolysis (ML) by the findings of microaneurysms (81%) and mesangial degeneration (70%) such as loose reticular matrix and poor matrix area. In addition, glomerular infiltration of mononuclear leukocytes including macrophages was noted in 70% of the cases. Glomerular enlargement was not correlated with the grade of hyperemia, but it was correlated with the grade of ML index of % glomeruli with microaneurysms (F = 7.22, p < 0.004). There was an inverse relationship between the grades of mesangial thickening and of the ML index (P < 0.005). The number of glomerular leukocytes was positively correlated with mean glomerular size (P < 0.002) and with the ML index (P < 0.03). Notably, the glomerular macrophage-positive c...Continue Reading

References

Aug 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M T HagleyJ Zarconi
Oct 1, 1991·Kidney International·I Ichikawi, R C Harris
Sep 1, 1991·The Journal of Clinical Investigation·S KourembanasD V Faller
May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K JohS Sakai
Oct 1, 1989·Kidney International·Y YoshidaI Ichikawa
Jun 1, 1987·Kidney International·V J Dzau
Nov 1, 1988·Circulation·J N Cohn
Jan 1, 1985·European Heart Journal·E BraunwaldP H Stone
Jan 1, 1968·Respiration; International Review of Thoracic Diseases·C A SorbiniG Muiesan
Sep 7, 1968·British Medical Journal·P J HiltonJ R Tighe
Nov 1, 1984·Circulation Research·I IchikawaB M Brenner
Jul 1, 1983·Kidney International·T Morita, J Churg
Dec 16, 1980·Biochemical and Biophysical Research Communications·E J GoetzlB U Wintroub
Apr 1, 1994·Kidney International·V Cattell
Oct 1, 1996·Journal of the American Society of Nephrology : JASN·T MatsusakaI Ichikawa
Feb 1, 1997·Kidney International·B K KrämerA Kurtz
Jan 1, 1997·Nephron·J D WalkerM Mauer
Mar 1, 1956·Circulation·J E EDWARDSC H SCHEIFLEY

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Citations

Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kunitoshi IsekiShuichi Takishita
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Donald SilverbergAdrian Iaina
Feb 23, 2010·Clinical and Experimental Nephrology·Carlo LonghiniFabio Fabbian
Dec 19, 2008·The American Journal of the Medical Sciences·Basil M PaulusKarl T Weber
Aug 12, 2006·International Journal of Cardiology·Kamran Akram, Brian L Pearlman
Nov 23, 2006·The American Journal of Medicine·Gregg C Fonarow, J Thomas Heywood
Jul 9, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Waichi SatoTakahiko Nakagawa
Jul 30, 2014·Journal of the American Society of Nephrology : JASN·Satoko HayakawaNoriyuki Ouchi
Jul 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Naoki TakahashiMasayuki Iwano

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