Mesenchymal chondrosarcoma in the young

Virchows Archiv. A, Pathological Anatomy and Histopathology
M Dabska, A G Huvos

Abstract

It has been almost a quarter of a century that this rare, still poorly understood and to date insufficiently studied, cartilage neoplasm was described. Based on 19 cases in the young representing 26 percent of chondrosarcoma patients under the age of 21 years, this study found equal sex distribution with the youngest patient being a 6-year old boy. Twelve lesions occurred between the ages of 16 and 21 years. All but one of the tumors arose in the skeleton with nearly half of them involving the lower extremity. Pain was inconsistent and rare at presentation in contrast to the regularity of swelling or a painless mass. Survival analysis revealed a 46 percent 2-year and a 35 percent 5-year survival rate, whereas at 10 years only 20 percent of the patients were still alive. This study attempts to establish the likeliest evolutionary pathway of neoplastic cell differentiation and traces the origin of this tumor to a neoplastic caricature of embryonal endochondral osteogenesis.

References

Oct 1, 1973·Cancer·G C SteinerP G Bullough
Sep 1, 1971·Cancer·A H SalvadorD C Dahlin
Jan 1, 1966·Cancer·R V HutterR S Sherman
Jan 1, 1966·Archives of Ophthalmology·M J Reeh
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·F J Martinez-Tello, J J Navas-Palacios
Jan 1, 1980·Skeletal Radiology·J Pringle, D J Stoker
Dec 1, 1958·Journal of Chronic Diseases·S J CUTLER, F EDERER
Mar 1, 1962·Cancer·D C DAHLIN, E D HENDERSON

❮ Previous
Next ❯

Citations

Apr 7, 2000·The American Journal of Pathology·T AignerT Kirchner
Nov 1, 1984·Acta Pathologica Japonica·N SatoK Kikuchi
Jan 3, 2012·Archives of Pathology & Laboratory Medicine·Rachel J ShakkedHoward D Dorfman
Mar 6, 2012·Orthopedics·Andreas F MavrogenisPanayiotis J Papagelopoulos
Jan 1, 1988·Journal of Oral Pathology·G E Garrington, W K Collett
Jul 1, 1985·Histopathology·J R VilanovaJ M Rivera-Pomar
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J M RohrbachH G Scheel-Walter
Dec 1, 1993·Cancer Genetics and Cytogenetics·L SainatiG Basso
Mar 6, 2007·The Journal of Hand Surgery·John T Anderson, George L Lucas
Feb 26, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Susanna MüllerThomas Aigner
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H WelkerlingG Delling
Jun 1, 1988·World Journal of Surgery·A G Huvos
Oct 19, 2017·Journal of Surgical Oncology·Yusuke TsudaAkira Kawai
May 28, 2013·Clinical Orthopaedics and Related Research·Satoshi KawaguchiValerae O Lewis
Mar 11, 2019·BMJ Case Reports·Choon Sean ChooRamiza Ramza Ramli
Mar 17, 2020·EFORT Open Reviews·Ajay Puri
Jan 1, 1994·Ultrastructural Pathology·J K MawadA G Ayala
Mar 16, 2016·Clinical Orthopaedics and Related Research·Brian A SchneidermanLukas M Nystrom
Feb 8, 2007·Archives of Pathology & Laboratory Medicine·Meera Hameed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.