Mesenchymal hamartoma of chest wall in infancy: natural history of two cases

Pediatric Pathology
J M Odell, D R Benjamin

Abstract

Two cases of mesenchymal hamartoma of chest wall in infancy are reported. These distinctive and rare lesions arise in the antenatal period, present at birth or in early life as chest wall masses with marked rib deformation, and may produce respiratory compromise through encroachment on the chest cavities. Histologically composed of chondroid and primitive mesenchymal elements with giant-cell formation, endochondral ossification, and maturation to trabecular bone, they exhibit some features of aneurysmal bone cyst. Because of their cellularity and proliferative appearance, they are often misinterpreted as sarcomas; however, they pursue a benign course and can be well managed surgically. Our cases possessed multiple chest wall masses that were clinically apparent at birth and sequentially resected over a period of several months, creating an opportunity to document their hitherto unreported histologic evolution. Their pattern of maturation is in keeping with a hamartomous malformation.

References

May 1, 1977·Cancer·D J RuiterE A van der Velde
Jun 1, 1979·Radiology·R A McLeod, D C Dahlin
Jun 1, 1985·The Journal of Pathology·C E du Boulay
Dec 1, 1974·American Journal of Diseases of Children·C M MayerW G Rainer
Jul 1, 1972·Radiology·B I BlumenthalJ A Kirkpatrick
Sep 1, 1970·Cancer·J L BieseckerV Miké
Jul 1, 1983·Human Pathology·H J Spjut, A G Ayala
Dec 1, 1982·Journal of Surgical Oncology·A N CampbellM G Mott
May 1, 1961·Cancer·A NASH, A P STOUT
Apr 1, 1965·Cancer·S L KAUFFMAN, A P STOUT
May 1, 1962·Cancer·M S LE BER, A P STOUT
Feb 1, 1948·Annals of Surgery·A P Stout

❮ Previous
Next ❯

Citations

Jan 1, 1989·Pediatric Radiology·A E SchlesingerJ J Swaney
Dec 7, 2005·Pediatric Surgery International·Bruce R Pawel, Timothy M Crombleholme
Mar 16, 2013·Pediatric Surgery International·Yelda JozaghiMiriam Blumenkrantz
Jan 1, 1991·Clinical Radiology·S J Gwyther, C M Hall
Apr 1, 1993·Thorax·S K JainS K Ramani
Jul 31, 1998·Seminars in Roentgenology·A K ShettyR D Craver
Apr 18, 2012·Fetal and Pediatric Pathology·Rong LiGene P Siegal
May 1, 1996·Journal of Pediatric Surgery·S TroumA S Besser
May 1, 1996·Journal of Pediatric Surgery·J PsailaW J Patrick
Jan 25, 2002·Pathology, Research and Practice·A Serrano-EgeaF J Martínez-Tello
May 17, 2006·International Journal of Surgical Pathology·Eliane M I AmstaldenAndrew E Rosenberg
Dec 30, 1999·Diagnostic Cytopathology·S A NicholsonL P Dehner
Oct 3, 1999·Pathology International·K KatoK Sekido
Apr 26, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Semsi AltanerKemal Kutlu
May 10, 2003·Der Pathologe·M GuschmannB Stöver
Apr 16, 1998·The American Journal of Surgical Pathology·M B McDermottL P Dehner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.