Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth.

Journal of Tissue Engineering and Regenerative Medicine
Wesley M JacksonRocky S Tuan

Abstract

The success of peripheral nerve regeneration is governed by the rate and quality of axon bridging and myelination that occurs across the damaged region. Neurite growth and the migration of Schwann cells is regulated by neurotrophic factors produced as the nerve regenerates, and these processes can be enhanced by mesenchymal stem cells (MSCs), which also produce neurotrophic factors and other factors that improve functional tissue regeneration. Our laboratory has recently identified a population of mesenchymal progenitor cells (MPCs) that can be harvested from traumatized muscle tissue debrided and collected during orthopaedic reconstructive surgery. The objective of this study was to determine whether the traumatized muscle-derived MPCs exhibit neurotrophic function equivalent to that of bone marrow-derived MSCs. Similar gene- and protein-level expression of specific neurotrophic factors was observed for both cell types, and we localized neurogenic intracellular cell markers (brain-derived neurotrophic factor and nestin) to a subpopulation of both MPCs and MSCs. Furthermore, we demonstrated that the MPC-secreted factors were sufficient to enhance in vitro axon growth and cell migration in a chick embryonic dorsal root ganglia (...Continue Reading

Associated Clinical Trials

May 28, 2019·Julia AV Nuelle

References

Jan 1, 1996·Methods in Cell Biology·R Nishi
Aug 10, 2000·Journal of Neuroscience Research·D WoodburyI B Black
Nov 24, 2004·Differentiation; Research in Biological Diversity·Tatiana TondreauDominique Bron
May 5, 2005·Experimental Neurology·P BossolascoE Polli
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·James R MunozDarwin J Prockop
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Jun 17, 2006·Cellular and Molecular Neurobiology·Gerburg KeilhoffHisham Fansa
Sep 9, 2006·Brain Research·Arianna ScuteriGiovanni Tredici
Jul 11, 2007·Journal of Cellular Physiology·Arnold I Caplan
Aug 7, 2007·International Journal of Hematology·Katsutoshi OzakiKeiya Ozawa
Oct 24, 2007·Journal of Internal Medicine·K Le Blanc, O Ringdén
Oct 24, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hung-Chuan PanShu-Peng Ho
Oct 27, 2007·Seminars in Hematology·Jakob Passweg, Alan Tyndall
Feb 23, 2008·Biotechnology and Applied Biochemistry·Daljeet MahaySusan G Shawcross
Jul 1, 2008·Experimental Cell Research·Daljeet MahaySusan G Shawcross
Nov 4, 2008·The Journal of Bone and Joint Surgery. American Volume·Leon J NestiRocky S Tuan
Jan 27, 2009·Journal of Tissue Engineering and Regenerative Medicine·W M JacksonR S Tuan
Feb 21, 2009·Neurosurgical Focus·Tessa Gordon
May 12, 2009·Neuroscience Research·Maria BrohlinLiudmila N Novikova
Jun 12, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wesley M JacksonRocky S Tuan
Oct 10, 2009·Neuro-Signals·Junhua XiaoSimon S Murray
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·Srinivas Madduri, Bruno Gander
Dec 7, 2010·Journal of Cellular and Molecular Medicine·Wesley M JacksonRocky S Tuan
Apr 1, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wesley M JacksonLeon J Nesti

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Citations

Sep 11, 2016·Stem Cell Research & Therapy·Heidi R Hofer, Rocky S Tuan
Dec 14, 2017·Scientific Reports·Ching-Wen HuangSong Li
Aug 29, 2020·The Journal of Bone and Joint Surgery. American Volume·Jaira F de VasconcellosLeon J Nesti
Jan 8, 2021·Stem Cell Research & Therapy·Marvin DingleLeon J Nesti

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