Mesenchymal stem cell basic research and applications in dog medicine

Journal of Cellular Physiology
Mudasir Bashir GugjooGutulla Taru Sharma

Abstract

The stem cells, owing to their special characteristics like self-renewal, multiplication, homing, immunomodulation, anti-inflammatory, and dedifferentiation are considered to carry an "all-in-one-solution" for diverse clinical problems. However, the limited understanding of cellular physiology currently limits their definitive therapeutic use. Among various stem cell types, currently mesenchymal stem cells are extensively studied for dog clinical applications owing to their readily available sources, easy harvesting, and ability to differentiate both into mesodermal, as well as extramesodermal tissues. The isolated, culture expanded, and characterized cells have been applied both at preclinical as well as clinical settings in dogs with variable but mostly positive results. The results, though positive, are currently inconclusive and demands further intensive research on the properties and their dependence on the applications. Further, numerous clinical conditions of dog resemble to that of human counterparts and thus, if proved rewarding in the former may act as basis of therapy for the latter. The current review throws some light on dog mesenchymal stem cell properties and their potential therapeutic applications.

References

Jul 1, 1997·The Veterinary Clinics of North America. Small Animal Practice·S A Johnston
Aug 11, 1998·The Journal of Bone and Joint Surgery. American Volume·S P BruderS Kadiyala
Apr 3, 2003·The Laryngoscope·Bernard RousseauDiane M Bless
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Songtao Shi, Stan Gronthos
Oct 18, 2003·The Journal of Bone and Joint Surgery. American Volume·Treena Livingston ArinzehSudha Kadiyala
Dec 5, 2003·The Annals of Otology, Rhinology, and Laryngology·Shin-Ichi KanemaruYasuhiko Shimizu
May 27, 2004·Investigative Ophthalmology & Visual Science·Stefano Barabino, M Reza Dana
Apr 28, 2005·Journal of Periodontal Research·Tatsuya AkizukiIsao Ishikawa
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Axel LinkePiero Anversa
Sep 13, 2005·The Journal of Thoracic and Cardiovascular Surgery·Imran A MemonHikaru Matsuda
Sep 29, 2006·The Journal of Small Animal Practice·G FluehmannA Jaggy
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jozef BartunekGuy R Heyndrickx
Nov 3, 2006·American Journal of Veterinary Research·Hiroaki KamishinaRoger M Clemmons
Apr 6, 2007·Cells, Tissues, Organs·Byung Joo LeeRobert R Lorenz
Sep 14, 2007·Pediatric Diabetes·Valeria HirschlerMauricio Jadzinsky
Nov 22, 2007·Journal of Neuroscience Research·Masaaki HokariYoshinobu Iwasaki
Jan 19, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Akihiko HiyamaDaisuke Sakai
Jan 25, 2008·The Journal of Craniofacial Surgery·André de Mendonça CostaMaria Rita Passos-Bueno
Feb 9, 2008·Drugs & Aging·Gary N Foulks
Nov 14, 2008·Expert Opinion on Pharmacotherapy·William H Ridder
Dec 24, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hiromichi OmaePeter C Amadio
Apr 29, 2009·Current Opinion in Ophthalmology·Mark B AbelsonCiera Maffei
Aug 19, 2009·Journal of Veterinary Science·Min-Soo SeoKyung-Sun Kang
Sep 29, 2009·Journal of Youth and Adolescence·Julie T Weismoore, Christianne Esposito-Smythers
Oct 7, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H El-MenoufyD Sabry
Dec 17, 2009·The Laryngoscope·Yoshihiko KumaiSteven M Zeitels

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