Mesenchymal stem cell exosomes in bone regenerative strategies-a systematic review of preclinical studies

Materials Today. Bio
S H S TanW S Toh

Abstract

The ability of bone for regeneration has long been recognized. However, once beyond a critical size, spontaneous regeneration of bone is limited. Several studies have focused on enhancing bone regeneration by applying mesenchymal stromal/stem cells (MSCs) in the treatment strategies. Despite the therapeutic efficacy of MSCs in bone regeneration, cell-based therapies are impeded by several challenges in maintaining the optimal cell potency and viability during expansion, storage, and final delivery to patients. Recently, there has been a paradigm shift in therapeutic mechanism of MSCs in tissue repair from one based on cellular differentiation and replacement to one based on secretion and paracrine signaling. Among the broad spectrum of trophic factors, extracellular vesicles ​particularly the exosomes have been reported to be therapeutically efficacious in several injury/disease indications, including bone defects and diseases. The current systematic review aims to summarize the results of the existing animal studies which were conducted to evaluate the therapeutic efficacy of MSC exosomes for bone regeneration. Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis ​guidelines, the PubMed and The Coch...Continue Reading

Citations

Oct 24, 2020·Macromolecular Bioscience·Carmen Gutierrez-MillanClara I Colino
Dec 11, 2020·Tissue Engineering. Part B, Reviews·Julika HuberNatalina Quarto
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Guo-Dong LuZhong Wang
Nov 24, 2020·Journal of Inflammation Research·Stuart B Goodman, Masahiro Maruyama
Dec 31, 2020·International Journal of Molecular Sciences·Martina GattiTullia Maraldi
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Marietta HerrmannSusanne Grässel
Jun 26, 2021·Stem Cell Reviews and Reports·Kosar MalekpourMajid Ahmadi
Jul 3, 2021·International Journal of Molecular Sciences·Sarah Hani ShoushrahEdda Tobiasch
Aug 31, 2021·The Journal of Investigative Dermatology·Anesh PrasaiAmina El Ayadi

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Methods Mentioned

BETA
X-ray
proteomics profiling

Software Mentioned

ARRIVE
SYRCLE

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