Mesenchymal Stem Cell Functionalization for Enhanced Therapeutic Applications

Tissue Engineering. Part B, Reviews
Dimitrios KouroupisDiego Correa

Abstract

Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact the standardization and reproducibility of their therapeutic potential. The identification of innate distinct functional MSC subpopulations, as well as the description of ex vivo protocols aimed at maintaining phenotypes and enhancing specific functions have the potential to overcome these limitations. The incorporation of those approaches into cell-based therapy would significantly impact the field, as more reproducible clinical outcomes may be achieved.

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Citations

Oct 1, 2020·Molecular and Cellular Biochemistry·Srividhya RaghavanMuthuswamy Balasubramanyam
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Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Clara Sanjurjo-RodriguezElena Jones
Feb 23, 2021·Frontiers in Bioengineering and Biotechnology·Carola SchmitzAntonina Lavrentieva
Mar 2, 2021·Frontiers in Bioengineering and Biotechnology·Dimitrios Kouroupis, Diego Correa
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Methods Mentioned

BETA
flow cytometry
dissection

Clinical Trials Mentioned

NCT01716481
NCT01849159
NCT02504437

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