Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway

Stem Cells and Development
Miho SongMyung-Soo Choo

Abstract

Interstitial cystitis (IC) is a syndrome characterized by urinary urgency, frequency, pelvic pain, and nocturia in the absence of bacterial infection or identifiable pathology. IC is a devastating disease that certainly decreases quality of life. However, the causes of IC remain unknown and no effective treatments or cures have been developed. This study evaluated the therapeutic potency of using human umbilical cord-blood-derived mesenchymal stem cells (UCB-MSCs) to treat IC in a rat model and to investigate its responsible molecular mechanism. IC was induced in 10-week-old female Sprague-Dawley rats via the instillation of 0.1 M HCl or phosphate-buffered saline (PBS; sham). After 1 week, human UCB-MSC (IC+MSC) or PBS (IC) was directly injected into the submucosal layer of the bladder. A single injection of human UCB-MSCs significantly attenuated the irregular and decreased voiding interval in the IC group. Accordingly, denudation of the epithelium and increased inflammatory responses, mast cell infiltration, neurofilament production, and angiogenesis observed in the IC bladders were prevented in the IC+MSC group. The injected UCB-MSCs successfully engrafted to the stromal and epithelial tissues and activated Wnt signaling cas...Continue Reading

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Citations

Jan 28, 2016·Current Opinion in Urology·Calvin LeeMargot S Damaser
Dec 22, 2015·Current Urology Reports·Aram KimMyung-Soo Choo
Nov 24, 2019·Stem Cell Reviews and Reports·Jung Hyun ShinMyung-Soo Choo
Dec 11, 2019·Neurourology and Urodynamics·Christopher ChermanskyApostolos Apostolidis
Apr 5, 2019·Neurourology and Urodynamics·Ji-Yeon HanMyung-Soo Choo
Jul 6, 2017·International Journal of Molecular Medicine·Jisun LimDong-Myung Shin
Apr 10, 2017·Archives of Gynecology and Obstetrics·Sourav Sanchit PatnaikVani Dandolu
Aug 28, 2019·Therapeutic Advances in Urology·Elliot B LanderJackie R See
Dec 26, 2021·Journal of Cellular and Molecular Medicine·Chao WenChenxia Hu

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Methods Mentioned

BETA
biopsies

Software Mentioned

Image Pro
GraphPad Prism

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