Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis

International Journal of Stem Cells
Hyunsuk JeongIl-Hoan Oh

Abstract

Mesenchymal stem cells (MSC) have emerged as breakthrough treatments for myocardial infarction. However, the efficacy of MSC remains unclear. The aim of the study was to evaluate treatment effect of MSC in terms of mechanical, regenerative, and clinical outcomes for patients with myocardial infarction (MI) using meta-analysis. A systematic search and critical review of MEDLINE, EMBASE, and Cochrane database literature published from inception through December 2017 was performed. The inclusion criteria were randomized controlled trials, studies on patients with myocardial infarction, and studies compared with placebo as a control group. A total of 950 patients from 14 randomized placebo controlled trials were included in the final meta-analysis. MSC treatment showed benefits for mechanical, regenerative, and clinical outcomes. In terms of mechanical outcomes, the LVEF of the MSC treatment group increased by 3.84% (95% CI: 2.32~5.35, I²=43) and the effect was maintained for up to 24 months. Regenerative outcomes were measured by scar mass and WMSI. Scar mass was reduced by -1.13 (95% CI: -1.80 to -0.46, I²=71) and WMSI was reduced by -0.05 (95% CI: -0.07 to -0.03, I²=45) at 6 months after MSC treatment. Mortality rate and inciden...Continue Reading

Citations

May 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Weiang YanSanjiv Dhingra
Nov 24, 2019·Stem Cell Reviews and Reports·Jung Hyun ShinMyung-Soo Choo
Aug 20, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
May 30, 2020·Current Atherosclerosis Reports·Ya-Ting ChenJing-Song Ou
Dec 14, 2018·Experimental and Therapeutic Medicine·Jiadi GanXiaodong Zhou
May 10, 2019·Journal of Extracellular Vesicles·Kenneth W WitwerSai Kiang Lim
Apr 17, 2020·Stem Cell Reviews and Reports·Philippe Hénon
Jan 10, 2019·Stem Cells International·Zhi ChenWei Eric Wang
May 24, 2019·Science Translational Medicine·Progyaparamita SahaSunjay Kaushal
Oct 30, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jack FeehanGustavo Duque
May 24, 2019·IScience·Mujib UllahAvnesh S Thakor
Feb 8, 2020·Cardiology in Review·Joseph Rudman, William H Frishman
Apr 23, 2021·Tissue Engineering and Regenerative Medicine·Thi-Tuong Van NguyenPhuc Van Pham
Apr 23, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Laura FieldsKen Suzuki
May 15, 2021·Regenerative Medicine·Gaia SpinettiPaolo Madeddu
Jun 5, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Michael Nguyen-TruongZhijie Wang
Jul 3, 2021·International Journal of Molecular Sciences·Jörg SchmehlStefanie Elser
Aug 9, 2021·Acta Biomaterialia·Sing Wan WongJae-Won Shin

❮ Previous
Next ❯

Software Mentioned

PRISMA
Review Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.