Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies

Clinical Pharmacology and Therapeutics
Deepaneeta SarmahPallab Bhattacharya

Abstract

Numerous preclinical studies have been carried out using mesenchymal stem cells (MSCs) therapy for ischemic stroke. The purpose of the present meta-analysis is to review the quality of preclinical studies. In all, 4,361 articles were identified, out of which 64 studies were included (excluding in vitro studies). The results were obtained across species, route, and time of administration, immunogenicity, and doses. The median quality score 4.90/10, confidence interval 95%, and large effect size were observed, which strongly supports the translation potential of MSC therapy for ischemic stroke.

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Citations

Jun 22, 2018·Translational Stroke Research·Deepaneeta SarmahPallab Bhattacharya
Nov 2, 2019·Journal of Cellular and Molecular Medicine·Xiaozheng LingZhifeng Deng
Jun 18, 2019·The International Journal of Neuroscience·Jackson SarafPallab Bhattacharya
Jun 25, 2020·Biotechnology and Bioengineering·Brent M BijonowskiTeng Ma
Apr 17, 2020·Current Topics in Medicinal Chemistry·Aishika DattaPallab Bhattacharya
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Mar 29, 2020·Translational Stroke Research·Aishika DattaPallab Bhattacharya
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Nov 22, 2019·Acta Biomaterialia·Hui X TanPeter J Crack
Oct 16, 2020·Journal of Stroke·Shuai ZhangXiaofeng Jia
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Aug 1, 2018·ACS Central Science·Jackson SarafDileep R Yavagal
Apr 25, 2019·ACS Chemical Neuroscience·Vignesh KotianPallab Bhattacharya

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