Mesenchymal stem cell transplantation in polytrauma: Evaluation of bone and liver healing response in an experimental rat model

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
Ayça Koca TanrıverdiYaşar Murat Elçin

Abstract

Trauma is the most common cause of death of young people in the world. As known, mesenchymal stem cells (MSCs) accelerate tissue regeneration mechanisms. In our study, we aimed to investigate the effects of MSCs transplantation on the healing of liver and bone tissue by considering trauma secondary inflammatory responses. 56 adult Wistar-albino rats were divided into two groups: the polytrauma (liver and bone) (n = 28), and the liver trauma group (n = 28). At 36 h and 5th day after surgery, both rats with polytrauma and with isolated liver injury received either intravenous (IV) or intraperitoneal (IP) injections of MSCs (one million cells per kg body weight). Untreated groups received IV and IP saline injections. At day 21 after surgery, liver, tibia and fibula of the subjects were excised and evaluated for histopathologic and histomorphometric examination. Additionally, whole blood count (white blood cells, hemoglobin and platelets), C-reactive protein (CRP), glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, blood gas, and trauma markers interleukin-1B (IL-1B), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha) levels were investigated. In general, MSC transplantations were wel...Continue Reading

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Citations

Feb 19, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Klemens Horst, Frank Hildebrand
Aug 26, 2020·Stem Cell Reviews and Reports·Selçuk ÖztürkYaşar Murat Elçin
Jan 10, 2021·Stem Cell Reviews and Reports·Lacy E LowryJames A Bynum

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