Mesenchymal stem cell treatment attenuates liver and lung inflammation after ethanol intoxication and burn injury

Alcohol
Brenda J CurtisElizabeth J Kovacs

Abstract

Cutaneous burn injury is one of the most devastating injuries one can obtain, with tissue damage extending beyond the skin wound to distal organs, including the gastrointestinal tract, liver, and lungs. Multiple organ failure is a leading cause of death after burn injury, resulting in excessive systemic and localized inflammation directly contributing to end organ damage. We postulated that the gut-liver-lung inflammatory axis underscores multiple organ failure in the context of burn injury and is hyper-activated when ethanol intoxication precedes burn. Mesenchymal stem cells (MSCs) are regenerative and anti-inflammatory, and MSC treatment has been shown to be beneficial in several immune disorders and injury models. Our objective was to determine whether intravenous infusion of exogenous bone marrow-derived MSCs could reduce post-burn and intoxication pulmonary, hepatic, and systemic inflammation. Vehicle- or ethanol- (1.6 g/kg) treated mice were subjected to sham or 15% total body surface area scald burn. One hour post-injury, mice were given 5 × 105 CFSE-labeled MSCs or phosphate-buffered saline intravenously (i.v.) and were euthanized 24 h later. We assessed circulating biomarkers of inflammation and liver damage, measured ...Continue Reading

Citations

Aug 28, 2020·European Journal of Immunology·Alexander HackelSven Brandau
Nov 22, 2020·Burns : Journal of the International Society for Burn Injuries·Filip RangatchewRikke Holmgaard
Aug 13, 2021·Stem Cell Research & Therapy·Raúl LópezFermín Sánchez-Guijo
Jan 23, 2021·Shock·Marisa E LuckMashkoor A Choudhry

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