Mesenchymal Stem Cell Treatment for Steroid Refractory Graft-versus-Host Disease in Children: A Pilot and First Study from Turkey

Stem Cells International
Fatih ErbeyGulyuz Ozturk

Abstract

This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infused. The median dose of MSC was 1.18 × 10(6) cells per kg body weight. Overall, complete response (CR) was documented in 18 patients, partial response (PR) was documented in 7 patients, and no response (NR) was documented in 8 patients. The 2-year estimated probability of overall survival (OS) for patients achieving CR and PR/NR was 63.8% and 29.4%, respectively (p = 0.0002). While the cumulative incidence of transplant related mortality (TRM) at day 100 after first MSC infusion was 46.6% in PR/NR patients, there was no any TRM at day 100 after first MSC infusion in CR patients (p = 0.001). Twelve patients developed chronic GVHD (cGVHD); eight of them were alive, with five having extensive disease and three having limited disease. In conclusion, MSCs appear to be safe and effective treatment option for pediatric patients with steroid refractory aGVHD. But the efficacy of MSCs on cGVHD in aGVHD patients treated with M...Continue Reading

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Citations

Feb 24, 2020·Stem Cell Reviews and Reports·Bernardo ZoehlerMaria Da Graça Bicalho
Jul 17, 2020·Frontiers in Immunology·Tik Shing CheungAntonio Galleu
Apr 14, 2020·Cancer Cell International·Xinyi ZhouBaoan Chen
Aug 1, 2018·Frontiers of Medicine·Shihua WangRobert Chunhua Zhao
Jun 19, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Arzu AkçayGülyüz Öztürk

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Methods Mentioned

BETA
density gradient centrifugation

Software Mentioned

SPSS ( Statistical Package for Social Sciences )

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