Mesenchymal stem cells and bone regeneration

Veterinary Surgery : VS
Karl H Kraus, C A Kirker-Head

Abstract

To review the role of mesenchymal stem cells (MSC) in bone formation and regeneration, and outline the development of strategies that use MSC in bone healing and regeneration. Literature review. Medline review, synopses of authors' published research. The MSC is the basic cellular unit of embryologic bone formation. Secondary bone healing mimics bone formation with proliferation of MSC then their differentiation into components of fracture callus. Bone regeneration, where large amounts of bone must form, mimics bone healing and can be achieved with MSC combined with strategies of osteogenesis, osteoinduction, osteoconduction, and osteopromotion. MSC based strategies first employed isolated and culture expanded stem cells in an osteoconductive carrier to successfully regenerate a critical segmental defect in the femur of dogs, which was as effective as autogenous cancellous bone. Because MSC appeared to be immunologically privileged, a study using mismatched allogeneic stem cells demonstrated that these cells would regenerate bone without inciting an immunologic response, documenting the possibility of banked allogeneic MSC for bone regeneration. A technique was developed for selectively retaining MSC from large bone marrow aspi...Continue Reading

References

Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Nov 1, 1994·Journal of Cellular Biochemistry·S P BruderA I Caplan
Aug 1, 1996·The Journal of Laboratory and Clinical Medicine·R M Winslow
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P CassiedeA I Caplan
Feb 1, 1997·Journal of Cellular Biochemistry·N JaiswalS P Bruder
Jul 1, 1997·Journal of Biomedical Materials Research·S L IshaugA G Mikos
May 19, 1998·Clinical Orthopaedics and Related Research·C A Kirker-HeadL A Carmel
Aug 11, 1998·The Journal of Bone and Joint Surgery. American Volume·S P BruderS Kadiyala
Dec 30, 1998·Calcified Tissue International·M MarcacciR Cancedda
Jan 6, 1999·The Journal of Bone and Joint Surgery. American Volume·J U YooB Johnstone
Jan 26, 1999·Clinical Orthopaedics and Related Research·D R CarterJ A Helms
Jan 26, 1999·Clinical Orthopaedics and Related Research·J U Yoo, B Johnstone
Jan 26, 1999·Clinical Orthopaedics and Related Research·S P BruderS Kadiyala
Apr 2, 1999·Science·M F PittengerD R Marshak
May 18, 1999·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·K H KrausS Bruder
Nov 5, 1999·Clinical Orthopaedics and Related Research·S P Bruder, B S Fox
Jul 6, 2000·The Orthopedic Clinics of North America·J E FlemingG F Muschler
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Mar 28, 2001·Journal of Dental Research·L F CooperS Kadiyala
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G F MuschlerK A Easley
May 30, 2001·Trends in Molecular Medicine·A I Caplan, S P Bruder
Feb 2, 2002·Experimental Hematology·Amelia BartholomewRonald Hoffman
Apr 9, 2002·Clinical Orthopaedics and Related Research·Robert W Bucholz
Apr 9, 2002·Clinical Orthopaedics and Related Research·George F Muschler, Ronald J Midura
Jun 6, 2002·Journal of Cellular Biochemistry. Supplement·Steven M Devine
Feb 5, 2003·Clinical Orthopaedics and Related Research·George F MuschlerKirk Easley
Apr 15, 2003·Veterinary Surgery : VS·Michael P KowaleskiKarl H Kraus
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Ranieri CanceddaRodolfo Quarto
Oct 18, 2003·The Journal of Bone and Joint Surgery. American Volume·Treena Livingston ArinzehSudha Kadiyala
Nov 25, 2003·Hematology·Michele H Cottler-FoxSteven Devine
Dec 16, 2003·Birth Defects Research. Part C, Embryo Today : Reviews·Frank P Barry
Feb 14, 2004·British Dental Journal·A Joshi, G C Kostakis
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Frank P Barry, J Mary Murphy
Mar 2, 2005·Clinical Orthopaedics and Related Research·George F MuschlerKimerly A Powell

❮ Previous
Next ❯

Citations

Jan 31, 2012·Cell and Tissue Research·Walter BrehmIris Ribitsch
Feb 27, 2007·Journal of Materials Science. Materials in Medicine·Borhane H FellahPierre Layrolle
Jun 1, 2012·New Zealand Veterinary Journal·R A WebsterG Vesey
Sep 25, 2009·Stem Cells and Development·Jaymi T TaianiDerrick E Rancourt
Feb 21, 2009·Tissue Engineering. Part a·Takeshi KikuchiMasaharu Takigawa
Dec 20, 2007·Implant Dentistry·Muna SoltanMichael D Rohrer
Sep 5, 2012·Cell Communication and Signaling : CCS·Ralf Hass, Anna Otte
Mar 21, 2012·Journal of Translational Medicine·Manoel Luiz FerreiraAlberto Schanaider
Mar 8, 2007·Critical Reviews in Eukaryotic Gene Expression·Gabi Shefer, Zipora Yablonka-Reuveni
Jul 28, 2011·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·R J FigueroaD H Betts
Oct 2, 2013·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·A Renwick, E Scurrell
Apr 21, 2012·Pakistan Journal of Biological Sciences : PJBS·Abd El-Kader Mahmoud Kholif
Jan 1, 2007·The Libyan Journal of Medicine·A NasefM Lopez
Jul 20, 2012·Annual Review of Biomedical Engineering·Mónica Beato CoelhoJeffrey M Karp
Jul 23, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Juan F BlancoMaria-Consuelo del Cañizo
May 24, 2013·The Veterinary Quarterly·Catharina De SchauwerEvelyne Meyer
Feb 3, 2016·Frontiers in Veterinary Science·Meghan O SullivanDominique J Griffon
Sep 8, 2012·Blood Cells, Molecules & Diseases·Meenal MehrotraAmanda C LaRue
Dec 6, 2011·Biotechnology Advances·Fa-Ming ChenSongtao Shi
Aug 30, 2011·The Veterinary Clinics of North America. Equine Practice·Peter I MilnerMatthew C Stewart
Jul 2, 2009·Cytotherapy·Jyoti A KodeAnandwardhan A Hardikar
Mar 27, 2007·Injury·Robert BielbyDennis McGonagle
Sep 17, 2008·Journal of Cellular Physiology·Agnieszka ArthurStan Gronthos
Aug 23, 2011·Journal of Biomedical Materials Research. Part a·E ProseckáE Amler
Apr 3, 2012·Journal of Pineal Research·William P ClafshenkelPaula A Witt-Enderby
Jan 22, 2011·Journal of Cellular and Molecular Medicine·Enrique Gómez-BarrenaFrank P Luyten
Dec 12, 2012·Veterinary Surgery : VS·Mandi J Lopez, Patrick R Daigle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.