Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences.

Cellular and Molecular Life Sciences : CMLS
Sabine Wislet-GendebienBernard Rogister

Abstract

The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crest stem cells (NCSC) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSC), including their similarities and differences. In this paper, using transcriptomic as well as proteomic technologies, we compared NCSC to MSC and stromal nestin-positive cells, all of them isolated from adult bone marrow. We demonstrated that the nestin-positive cell population, which was the first to be described as able to differentiate into functional neurons, was a mixed population of NCSC and MSC. More interestingly, we demonstrated that MSC shared with NCSC the same ability to truly differentiate into Tuj1-positive cells when co-cultivated with paraformaldehyde-fixed cerebellar granule neurons. Altogether, those results suggest that both NCSC and MSC can be considered as important tools for cellular therapies in order to replace neu...Continue Reading

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Citations

Sep 5, 2012·Cell Communication and Signaling : CCS·Ralf Hass, Anna Otte
Feb 21, 2014·Microbial Cell Factories·Rasoul ShafieiPhilippe Thonart
Oct 26, 2013·Cellular and Molecular Life Sciences : CMLS·Iain R MurrayBruno Péault
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Feb 16, 2019·Stem Cells and Development·Mikiya BeppuShinichi Yoshimura
Apr 20, 2018·Genesis : the Journal of Genetics and Development·Julien DebbacheLukas Sommer
Dec 10, 2020·Stem Cells Translational Medicine·Andreas BruzeliusTania Ramos-Moreno
Apr 4, 2021·Cells·Agnieszka KaminskaAnna Sarnowska
Jun 3, 2021·International Journal of Molecular Sciences·Myung Chul YooSeung Geun Yeo

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