Mesenchymal Stem Cells as Endogenous Regulators of Inflammation

Advances in Experimental Medicine and Biology
Hafsa MunirHelen M McGettrick

Abstract

This chapter discusses the regulatory role of endogenous mesenchymal stem cells (MSC) during an inflammatory response. MSC are a heterogeneous population of multipotent cells that normally contribute towards tissue maintenance and repair but have garnered significant scientific interest for their potent immunomodulatory potential. It is through these physicochemical interactions that MSC are able to exert an anti-inflammatory response on neighbouring stromal and haematopoietic cells. However, the impact of the chronic inflammatory environment on MSC function remains to be determined. Understanding the relationship of MSC between resolution of inflammation and autoimmunity will both offer new insights in the use of MSC as a therapeutic, and also their involvement in the pathogenesis of inflammatory disorders.

Citations

Jun 13, 2019·Stem Cells Translational Medicine·Mario RomanoAntonio Recchiuti
Feb 13, 2020·Frontiers in Cell and Developmental Biology·Nicolas CollaoMichael De Lisio
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Dongsheng Jiang, Karin Scharffetter-Kochanek
Sep 24, 2020·Stem Cells International·Rou ZhaoBin Zhang
Nov 1, 2020·Cell Death & Disease·Tiemei LiZhengqi Lu
Oct 26, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zijun ZhangLew Schon
Apr 4, 2021·International Journal of Molecular Sciences·Enzo ManchonReem Al-Daccak
Apr 10, 2021·Biochemistry. Biokhimii︠a︡·Nataliya A PetinatiValeriy G Savchenko
May 4, 2021·Frontiers in Bioengineering and Biotechnology·Jonathan Klavert, Bram C J van der Eerden
Sep 12, 2021·Scientific Reports·Hexuan NiuXishuai Wang

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